Association between BNT162b2 vaccination and reported incidence of post-COVID-19 symptoms: cross-sectional study 2020-21, Israel.
Association between BNT162b2 vaccination and reported incidence of post-COVID-19 symptoms: cross-sectional study 2020-21, Israel.
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DOI：
10.1038/s41541-022-00526-5
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发表时间：
2022-08-26
期刊：
影响因子：
9.2
通讯作者：
中科院分区：
文献类型：
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2019冠状病毒病（COVID-19）疫苗对大部分患者表现出的长期COVID-19症状的有效性尚不清楚。我们确定接种BNT 162 b2 mRNA疫苗是否与SARS-CoV-2感染后报告长期症状的发生率相关。我们邀请2020年3月至2021年11月期间在参与医院接受SARS-CoV-2感染PCR检测的个人填写在线问卷，其中包括人口统计学信息，急性COVID-19发作和他们目前正在经历的症状。使用二项回归，我们比较了接种疫苗的人与未接种疫苗的人和未感染的人，在急性后自我报告的症状。在951名感染者中，637人（67%）接种了疫苗。在研究人群中，最常见的症状是：疲劳（22%）、头痛（20%）、四肢无力（13%）和持续性肌肉疼痛（10%）。在调整了年龄、从症状开始到对调查作出反应的时间以及基线症状后，接受两次疫苗接种的人比未接种疫苗的人报告任何这些症状的可能性都要小。（疲劳、头痛、四肢无力、持续性肌肉疼痛）分别减少62%、50%、62%和66%，（风险比为0.38、0.50、0.38、0.34，p < 0.04）。与纳入的2447名从未报告过SARS-CoV-2感染的个体相比，双重接种疫苗的参与者报告任何上述症状的可能性都没有增加。接种2剂以上BNT 162 b2疫苗与报告大多数常见急性后COVID-19症状的风险降低相关。我们的研究结果表明，BNT 162 b2疫苗接种可能对长期COVID-19症状具有保护作用。
The effectiveness of Coronavirus disease 2019 (COVID-19) vaccines against the long-term COVID-19 symptoms expressed by a substantial proportion of patients is not well understood. We determined whether vaccination with the BNT162b2 mRNA vaccine was associated with incidence of reporting long-term symptoms post-SARS-CoV-2 infection. We invited individuals PCR-tested for SARS-CoV-2 infection at participating hospitals between March 2020 and November 2021 to fill an online questionnaire that included information about demographics, acute COVID-19 episode and symptoms they were currently experiencing. Using binomial regression, we compared vaccinated individuals with those unvaccinated and those uninfected, in terms of post-acute self-reported symptoms. Of the 951 infected, 637(67%) were vaccinated. In the study population, the most prevalent symptoms were: fatigue (22%), headache (20%), weakness of limbs (13%), and persistent muscle pain (10%). After adjusting for age, time from beginning of symptoms to responding to the survey, and baseline symptoms, those who received two vaccine doses were less likely than unvaccinated individuals to report any of these symptoms (fatigue, headache, weakness of limbs, persistent muscle pain) by 62%, 50%, 62%, and 66% respectively, (Risk ratios 0.38, 0.50, 0.38, 0.34, p < 0.04 in the listed sequence). Compared to the 2447 included individuals who never reported SARS-CoV-2 infection, double-vaccinated participants were no more likely to report any of the mentioned symptoms. Vaccination with 2+ doses of BNT162b2 was associated with a reduced risk of reporting most of the common post-acute COVID-19 symptoms. Our results suggest that BNT162b2 vaccination may have a protective effect against longer term COVID-19 symptoms.
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DOI：
10.1016/j.cmi.2021.07.041
发表时间：
2021-11
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
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影响因子：
17.3
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10.1016/s0140-6736(21)00677-2
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2021-05-01
期刊：
Lancet (London, England)
影响因子：
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作者：
Vasileiou E;Simpson CR;Shi T;Kerr S;Agrawal U;Akbari A;Bedston S;Beggs J;Bradley D;Chuter A;de Lusignan S;Docherty AB;Ford D;Hobbs FR;Joy M;Katikireddi SV;Marple J;McCowan C;McGagh D;McMenamin J;Moore E;Murray JL;Pan J;Ritchie L;Shah SA;Stock S;Torabi F;Tsang RS;Wood R;Woolhouse M;Robertson C;Sheikh A
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