Increased QT dispersion in patients with vasospastic angina
Increased QT dispersion in patients with vasospastic angina
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DOI：
10.1161/01.cir.98.5.435
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发表时间：
1998-08-04
期刊：
影响因子：
37.8
通讯作者：
Hiraoka, M
中科院分区：
文献类型：
--
作者：
Suzuki, M;Nishizaki, M;Hiraoka, M
冠状动脉痉挛患者发生室性心律失常的危险因素尚未确定。我们评估了血管痉挛性心绞痛患者的QT离散度及其与心肌缺血和再灌注期间室性心律失常易感性的关系。方法和结果-我们评估了冠状动脉内注射乙酰胆碱诱导冠状动脉痉挛前的校正QT（QTc）离散度在50例血管痉挛性心绞痛患者和50例非典型胸痛患者中，观察了硝酸异山梨酯（基线）和给药后30分钟的变化。血管痉挛性心绞痛患者的基线QTc离散度显著大于非典型胸痛患者（平均值+/-SD：69+/-24 vs 44+/-19 ms，平均差异的95%置信区间[CI]：16 - 33 ms; P
Background-The risk factors for ventricular arrhythmias in patients with coronary vasospasm have not been identified. We evaluated QT dispersion in patients with vasospastic angina and its relation to susceptibility to ventricular arrhythmias during myocardial ischemia and reperfusion.Methods and Results-We assessed the corrected QT (QTc) dispersion before induction of coronary artery spasm by intracoronary injection of acetylcholine (baseline) and 30 minutes after administration of isosorbide dinitrate in 50 patients with vasospastic angina and 50 patients with atypical chest pain. The baseline QTc dispersion was significantly greater in patients with vasospastic angina than in patients with atypical chest pain (mean+/-SD: 69+/-24 versus 44+/-19 ms, 95% confidence interval of mean difference [CI]: 16 to 33 ms; P