Implementation and workflow for PET monitoring of therapeutic ion irradiation: a comparison of in-beam, in-room, and off-line techniques
Implementation and workflow for PET monitoring of therapeutic ion irradiation: a comparison of in-beam, in-room, and off-line techniques
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DOI：
10.1088/0031-9155/56/5/004
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发表时间：
2011-03-07
影响因子：
3.5
通讯作者：
Enghardt, Wolfgang
中科院分区：
文献类型：
--
作者：
Shakirin, Georgy;Braess, Henning;Enghardt, Wolfgang
使用正电子发射断层扫描（PET）可以对离子治疗中的剂量传递进行独立评估。为此，在照射期间或之后测量作为治疗束的离子与被照射组织之间相互作用的结果而出现的正电子发射器的分布。本文考虑了在各种治疗设施中实施PET监测的三个概念。束内PET概念依赖于通过PET扫描仪与照射同时进行的PET测量，PET扫描仪完全集成到照射部位。室内PET概念允许在照射后立即通过安装在非常靠近照射地点的独立PET扫描仪进行测量。在脱机PET情况下，通过独立的PET/CT扫描仪在照射后10-30分钟进行测量。根据图像质量标准、集成成本及其对放疗工作流程的影响对这三个概念进行评估。梁内PET表现最好。然而，这种模式的集成成本估计非常高。此外，束流内PET的性能在很大程度上取决于加速器的类型和占空比。室内PET被建议用于计划治疗设施，作为测量数据质量和整合工作之间的良好折衷。对于靠近核医学部门的设施，在几种情况下可以建议离线PET。
An independent assessment of the dose delivery in ion therapy can be performed using positron emission tomography (PET). For that a distribution of positron emitters which appear as the result of interaction between ions of the therapeutic beam and the irradiated tissue is measured during or after the irradiation. Three concepts for PET monitoring implemented in various therapy facilities are considered in this paper. The in-beam PET concept relies on the PET measurement performed simultaneously to the irradiation by means of a PET scanner which is completely integrated into the irradiation site. The in-room PET concept allows measurement immediately after irradiation by a standalone PET scanner which is installed very close to the irradiation site. In the off-line PET scenario the measurement is performed by means of a standalone PET/CT scanner 10-30 min after the irradiation. These three concepts were evaluated according to image quality criteria, integration costs, and their influence onto the workflow of radiotherapy. In-beam PET showed the best performance. However, the integration costs were estimated as very high for this modality. Moreover, the performance of in-beam PET depends heavily on type and duty cycle of the accelerator. The in-room PET is proposed for planned therapy facilities as a good compromise between the quality of measured data and integration efforts. For facilities which are close to the nuclear medicine departments off-line PET can be suggested under several circumstances.