Dietary fiber and colon cancer: animal model studies.
Dietary fiber and colon cancer: animal model studies.
复制标题
DOI：
10.1016/0091-7435(87)90072-7
复制
发表时间：
1987-07
影响因子：
5.1
通讯作者：
Bandaru S. Reddy
中科院分区：
文献类型：
--
作者：
Bandaru S. Reddy
营养流行病学研究支持某些膳食纤维在结肠癌病因学中的保护作用。增加含纤维食物的摄入量和减少膳食脂肪摄入量的建议应该构成一种不太可能对人体造成伤害的饮食基础，并可能有可能减少人类结肠癌的发生。在动物模型中考察膳食纤维作为结肠癌抑制剂的作用的研究似乎提供了一些相互矛盾的结果，主要是由于用于诱发结肠癌的致癌物质的性质和数量的不同，实验饮食的组成不同，以及动物食物摄入量的相对差异，列举了一些方法学问题。然而，总体而言，与其他膳食纤维来源相比，饲喂小麦麸皮似乎在更大程度上抑制了彩色肿瘤的发展。
Support for a protective role for certain dietary fibers in the etiology of colon cancer has come from nutritional epidemiologic studies. Recommendations to increase consumption of fiber-containing food and decrease the intake of dietary fat should form the basis of a diet that is unlikely to do harm, and may have the potential for reducing the development of colon cancer, in humans. Studies examining the role of dietary fiber as an inhibitor of colon cancer in animal models appear to have provided some conflicting results, due mostly to differences in the nature and amount of carcinogen used to induce colon tumors, variation in the composition of the experimental diets, and relative differences in food intake by animals, to cite a few of the methodological problems. However, overall, the feeding of wheat bran appears to inhibit color tumor development to a greater degree than do other dietary sources of fiber.