An investigation of language impairment in autism: Implications for genetic subgroups
An investigation of language impairment in autism: Implications for genetic subgroups
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DOI：
10.1080/01690960042000058
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发表时间：
2001-04-01
期刊：
影响因子：
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通讯作者：
Tager-Flusberg, H
中科院分区：
文献类型：
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作者：
Kjelgaard, MM;Tager-Flusberg, H
自闭症涉及语言和沟通方面的主要障碍，但近年来研究的主要焦点一直是定义人群的沟通缺陷。本文报道的研究调查了一组89名使用ADI-R诊断为自闭症的儿童的语言功能，并符合DSM-IV标准。这些年龄在4岁到14岁之间的儿童接受了一系列标准化的语言测试，这些测试涉及语音、词汇和高阶语言能力。主要发现是，在自闭症儿童中，他们的语言技能存在显着的异质性，尽管在所有儿童中，发音技能都幸免于难。自闭症儿童的不同亚组是根据他们在语言测试中的表现来确定的。一些自闭症儿童的语言能力正常;对于其他儿童，他们的语言能力明显低于年龄预期。自闭症语言障碍儿童的标准化测量的表现概况与定义障碍特异性语言障碍（或SLI）的概况相似。这个语言障碍的自闭症亚组的遗传学和自闭症和SLI的定义的理解的影响进行了讨论。
Autism involves primary impairments in both language and communication, yet in recent years the main focus of research has been on the communicative deficits that define the population. The study reported in this paper investigated language functioning in a group of 89 children diagnosed with autism using the ADI-R, and meeting DSM-IV criteria. The children, who were between 4 and 14 years old, were administered a battery of standardised language tests tapping phonological, lexical, and higher-order language abilities. The main findings were that among the children with autism there was significant heterogeneity in their language skills, although across all the children, articulation skills were spared. Different subgroups of children with autism were identified on the basis of their performance on the language measures. Some children with autism have normal language skills; for other children, their language skills are significantly below age expectations. The profile of performance across the standardised measures for the language-impaired children with autism was similar to the profile that defines the disorder specific language impairment (or SLI). The implications of this language impaired subgroup in autism for understanding the genetics and definition of both autism and SLI are discussed.