Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging.
Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging.
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DOI：
10.1021/acsami.7b09608
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发表时间：
2017-11
影响因子：
9.5
通讯作者：
L. Qin;Ziyan Sun;K. Cheng;Shu-wen Liu;Jian‐xin Pang;L. Xia;Wen-Hua Chen;Zhen Cheng;Jin-Xiang Chen
中科院分区：
文献类型：
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作者：
L. Qin;Ziyan Sun;K. Cheng;Shu-wen Liu;Jian‐xin Pang;L. Xia;Wen-Hua Chen;Zhen Cheng;Jin-Xiang Chen
Two water-stable three-dimensional Mn- and Gd-based metal-organic frameworks (MOFs), {[Mn2(Cmdcp)2(H2O)2]·H2O}n (1) and {[Gd(Cmdcp)(H2O)3](NO3)·3H2O}n (2, H3CmdcpBr = N-(4-carboxy benzyl)-(3,5-dicarboxyl)pyridinium bromide), have been prepared and analyzed. In vitro magnetic resonance imaging indicated that MOFs 1 and 2 possess relaxivity r1 values of 17.50 and 13.46 mM-1·S-1, respectively, which are superior to that of the control Gd-DTPA (r1 = 4.87 mM-1·S-1, DTPA = diethylene triamine pentaacetate). MOFs 1 and 2 also possessed good biocompatibility and low cytotoxicity against a model cell line. In vivo magnetic resonance images of treated Kunming mice indicated that kidneys showed remarkably positive signal enhancement after 15 min with intravenous administration of MOF 1 and the hyperintensity of both kidneys persisted for about 240 min with no obvious tissue damage. MOF 1 is therefore promising in vivo probes for imaging intravascular diseases and renal dysfunction.
