Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging
Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging
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DOI：
10.1002/anie.201100299
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Chou, Pi-Tai
中科院分区：
文献类型：
--
作者：
Liu, Chien-Liang;Wu, Hung-Tsung;Chou, Pi-Tai
追求黄金：所制备的胰岛素-金纳米簇(NCS)显示出强烈的红色荧光，良好的生物相容性，并在降血糖方面保持了天然的胰岛素生物活性。它们在应用中的多功能性通过荧光成像、X射线计算机断层扫描和胰岛素抑制物相互作用(见图；IDE=胰岛素降解酶)得到证明。
Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE= insulin-degrading enzyme).