Human brain diffusion tensor imaging at submillimeter isotropic resolution on a 3Tesla clinical MRI scanner.
Human brain diffusion tensor imaging at submillimeter isotropic resolution on a 3Tesla clinical MRI scanner.
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DOI：
10.1016/j.neuroimage.2015.06.016
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发表时间：
2015-09
期刊：
影响因子：
5.7
通讯作者：
Chen NK
中科院分区：
文献类型：
--
作者：
Chang HC;Sundman M;Petit L;Guhaniyogi S;Chu ML;Petty C;Song AW;Chen NK
高分辨率扩散张量成像（DTI）的优点已经在最近的死后人脑研究中得到证实（米勒等人，NeuroImage 2011; 57（1）：167-181），显示了可以在亚毫米各向同性分辨率的数据中更准确地检测到白色物质纤维束。据我们所知，在亚毫米各向同性分辨率的活体人脑DTI尚未常规实现，因为在DTI扫描中难以同时实现高分辨率和高信噪比（SNR）。本文报道了一种结合多路敏感性编码（MUSE）重建的3D多层交错EPI采集，在3 T临床MRI扫描仪上实现了高质量、高SNR和亚毫米级各向同性分辨率（0.85 × 0.85 × 0.85 mm 3）的活体人脑DTI。与先前报道的死后人脑DTI研究一致，我们的体内数据表明，与传统DTI相比，高分辨率DTI可以更准确和完整地映射人脑的结构连接网络（例如，2 × 2 × 2 mm3）。
The advantages of high-resolution diffusion tensor imaging (DTI) have been demonstrated in a recent post-mortem human brain study (Miller et al., NeuroImage 2011;57(1):167–181), showing that white matter fiber tracts can be much more accurately detected in data at submillimeter isotropic resolution. To our knowledge, in vivo human brain DTI at submillimeter isotropic resolution has not been routinely achieved yet because of the difficulty in simultaneously achieving high resolution and high signal-to-noise ratio (SNR) in DTI scans. Here we report a 3D multi-slab interleaved EPI acquisition integrated with multiplexed sensitivity encoded (MUSE) reconstruction, to achieve high-quality, high-SNR and submillimeter isotropic resolution (0.85 × 0.85 × 0.85 mm3) in vivo human brain DTI on a 3 Tesla clinical MRI scanner. In agreement with the previously reported post-mortem human brain DTI study, our in vivo data show that the structural connectivity networks of human brains can be mapped more accurately and completely with high-resolution DTI as compared with conventional DTI (e.g., 2 × 2 × 2 mm3).