Anti-idiotype antibodies as potential therapeutic agents for human breast cancer.
Anti-idiotype antibodies as potential therapeutic agents for human breast cancer.
复制标题
抗独特型抗体作为人类乳腺癌的潜在治疗剂。
DOI：
10.1007/978-1-4615-2443-4_13
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发表时间：
1994
影响因子：
--
通讯作者：
Foon,KA
中科院分区：
文献类型：
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作者：
Bhattacharya-Chatterjee,M;Mrozek,E;Mukerjee,S;Ceriani,RL;Kohler,H;Foon,KA
乳腺癌是女性癌症死亡的最常见原因。复发性乳腺癌不能通过标准疗法治愈，需要新的治疗方法。本研究的目的是采用一种替代和安全的方法，使用单克隆抗独特型（Id）抗体在两个概念上不同的方式对乳腺癌患者进行免疫治疗。在第一种方法中，模拟乳腺癌肿瘤相关抗原（TAA）的单克隆抗Id抗体将用于主动免疫患者以产生抗肿瘤免疫。在第二种方法中，将使用单克隆抗Id抗体从既往接受放射性标记的单克隆抗乳腺TAA抗体治疗的患者的循环中清除不需要的过量放射性。
Breast cancer is the most common cause of cancer deaths in women. Recurrent breast cancer is not curable by standard therapies and new therapeutic approaches are needed. The goal of this study is to employ an alternative and safe approach to immunotherapy of breast cancer patients using monoclonal anti-idiotype (Id) antibodies in two conceptually different ways. In the first approach, monoclonal anti-Id antibodies which mimic breast cancer tumor-associated antigens (TAA) will be used to actively immunize patients for the production of anti-tumor immunity. In the second approach, monoclonal anti-Id antibodies will be used to remove unwanted excess radioactivity from the circulation of patients previously treated with radiolabeled monoclonal anti-breast TAA antibodies.