Head circumference and height in autism: A study by the Collaborative Program of Excellence in Autism
Head circumference and height in autism: A study by the Collaborative Program of Excellence in Autism
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DOI：
10.1002/ajmg.a.31465
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发表时间：
2006-11-01
影响因子：
2
通讯作者：
Volkmar, Fred
中科院分区：
文献类型：
--
作者：
Lainhart, Janet E.;Bigler, Erin D.;Volkmar, Fred
来自NICHD/NIDCD自闭症卓越合作项目的10个站点的数据被结合起来，以研究头围的分布以及与人口统计学和临床变量的关系。338名自闭症谱系障碍（ASD）先证者，包括208名自闭症先证者，与147名父母、149名兄弟姐妹和典型的对照组一起进行了沿着研究。ASD被诊断，头围和临床变量在所有网站以标准化的方式测量。所有自闭症受试者均符合ADI-R、ADOS-G、DSM-IV和ICD-10标准。结果表明：孤独症患儿标准头围的分布呈正态分布，其平均值、方差和大头畸形率均增高，而小头畸形率无增高。自闭症患者的头围往往相对于身高较大。没有网站，性别，年龄，社会经济地位，语言，或非语言智商的影响存在于自闭症样本。除了自闭症本身，标准化身高和父母平均头围是预测自闭症患者头围的最重要因素。自闭症先证者及其父母的平均标准头围和大头畸形率相似。头围增加与更高（更严重）的ADI-R社交算法评分相关。大头畸形与语言延迟发作有关。虽然孤独症患者的平均头围和大头畸形率增加，但存在高度的变异性，强调了该疾病复杂的临床异质性。自闭症患者头围的广泛分布对遗传学、神经影像学和其他神经生物学研究具有重要意义。(c)2006威利-利斯公司
Data from 10 sites of the NICHD/NIDCD Collaborative Programs of Excellence in Autism were combined to Study the distribution of head circumference and relationship to demographic and clinical variables. Three hundred thirty-eight probands with autism-spectruin disorder (ASD) including 208 probands with autism were studied along with 147 parents: 149 siblings, and typically developing controls. ASDs were diagnosed, and head circumference and clinical variables measured in a standardized manner across all sites. All Subjects with autism met ADI-R, ADOS-G, DSM-IV, and ICD-10 criteria. The results show the distribution of standardized head circumference in autism is normal in shape, and the mean, variance; and rate of macrocephaly but not microcephaly are increased. Head circumference tends to be large relative to height in autism. No site, gender, age, SES, verbal, or non-verbal IQ effects were present in the autism sample. In addition to autism itself, standardized height and average parental head circumference were the most important factors predicting head circumference in individuals with autism. Mean standardized head circumference and rates of macrocephaly were similar in probands with autism and their parents. Increased head circumference was associated with a higher (more severe) ADI-R social algorithm score. Macrocephaly is associated with delayed onset of language. Although mean head circumference and rates of macrocephaly are increased in autism, a high degree of variability is present, underscoring the complex clinical heterogeneity of the disorder. The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research. (c) 2006 Wiley-Liss, Inc.