The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation.
The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation.
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PKR 蛋白激酶 - 细胞生长和分化的干扰素诱导调节剂。
DOI：
10.1016/s0925-5710(96)00544-0
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发表时间：
1997
影响因子：
2.1
通讯作者：
Tanaka,H
中科院分区：
文献类型：
--
作者：
Samuel,CE;Kuhen,KL;George,CX;Ortega,LG;Rende-Fournier,R;Tanaka,H
蛋白质磷酸化等翻译后修饰提供了一种重要的机制，通过这种机制可以控制蛋白质的功能活性，从而调节生物过程。干扰素（IFN）是一个多基因细胞因子家族，可以深刻影响动物细胞的多种功能，包括病毒复制、细胞生长和分化以及免疫反应。ifn诱导的rna依赖性蛋白激酶（PKR）介导的蛋白磷酸化变化与ifn介导的细胞增殖控制有关。我们对PKR的结构、调控和功能的了解将在这篇简短的综述中进行总结，重点是涉及PKR的蛋白磷酸化和干扰素作用的那些方面，这些方面是PKR在控制细胞生长和增殖中的核心作用。
Post-translational modifications such as protein phosphorylation provide an important mechanism by which the functional activity of proteins can be controlled and, hence, biological processes regulated. Interferons (IFN) are a multigene family of cytokines that can profoundly affect a wide variety of functions in animal cells including virus replication, cell growth and differentiation, and the immune response. Changes in protein phosphorylation mediated by the IFN-inducible, RNA-dependent protein kinase (PKR) are implicated in the control of cell proliferation mediated by IFNs. Our knowledge of the structure, regulation and function of PKR will be summarized in this brief review, with focus on those aspects of protein phosphorylation and interferon action involving PKR that are central to the roles of the enzyme in the control of cell growth and proliferation.