Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents
Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents
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DOI：
10.1002/cmdc.200600010
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发表时间：
2006-06-01
期刊：
影响因子：
3.4
通讯作者：
Kozikowski, Alan P.
中科院分区：
文献类型：
--
作者：
Jayaprakash, Sarva;Iso, Yasuyoshi;Kozikowski, Alan P.
潜在的新型结核病治疗方法：甲氟喹（1），一种具有简单但有趣的结构特征的抗疟疾药物，已被发现对结核分枝杆菌具有活性。因此，这种分子是一个很好的候选人作为一个领导化合物在寻找新的结核病药物。甲氟喹类似物的设计和合成的描述，并对结核病生物体的生物数据也提出。
Potential new tuberculosis treatment: Mefloquine (1), an antimalarial drug with simple, yet interesting structural features has been found to be active against Mycobacterium tuberculosis. Thus, this molecule is a good candidate as a lead compound in the search for new TB drugs. The design and synthesis of mefloquine analogues is described, and biological data against the TB organism are also presented.