Potential Role of Human Growth Hormone in Melanoma Growth Promotion
Potential Role of Human Growth Hormone in Melanoma Growth Promotion
复制标题
DOI：
10.1001/archdermatol.2012.2149
复制
发表时间：
2012-10-01
影响因子：
--
通讯作者：
Grichnik, James M.
中科院分区：
文献类型：
--
作者：
Handler, Marc Z.;Ross, Andrew L.;Grichnik, James M.
背景：人类生长激素(HGH)和胰岛素样生长因子-1(IGF-1)已被证明在多种癌症的恶性转化和进展中发挥作用。HGH还被认为可以上调与黑色素瘤发病有关的分子信号通路。尽管HGH以前被认为与促进良性和恶性黑素细胞肿瘤的临床生长有关，但据我们所知，没有确凿的研究表明HGH治疗后黑色素瘤的风险增加。然而，有报道称HGH与其他激素或照射后发生黑色素瘤。观察：一名49岁的白人男子出现新的色素丘疹，被诊断为黑色素瘤。患者报告在诊断前使用生长激素3个月。他的妻子，51岁，也是白人，也使用外源性HGH 3个月，并在2周前被诊断为黑色素瘤。结论：考虑到两个不相关的人在短时间内发生黑色素瘤的可能性不大，有理由认为共同的环境因素(HGH或其他共同暴露)导致了这两种黑色素瘤的发生。由于外源性HGH作为抗衰老药物的使用越来越多，因此了解这种激素的促生长作用是很重要的。在有更好的数据确定外源性HGH的真实风险之前，它作为抗衰老药物的使用值得加强监测。阿奇皮马托尔。2012年；148(10)：1179-1182
Background: Human growth hormone (HGH) and insulin-like growth factor-1 (IGF-1) have been shown to play a role in the malignant transformation and progression of a variety of cancers. HGH is also known to up-regulate molecular signaling pathways implicated in the pathogenesis of melanoma. Although HGH has previously been implicated in promoting the clinical growth of both benign and malignant melanocytic neoplasms, to our knowledge there are no conclusive studies demonstrating an increased risk of melanoma following HGH therapy. Nevertheless, there are reports of melanoma developing subsequent to HGH coadministered with either other hormones or following irradiation.Observation: A 49-year-old white man presented with a new pigmented papule that was diagnosed as melanoma. The patient reported using HGH for 3 months prior to the diagnosis. His 51-year-old wife, who also was white, had also been using exogenous HGH for 3 months and had been diagnosed as having a melanoma 2 weeks prior.Conclusions: Given the unlikelihood of 2 unrelated people developing melanoma within a short time span, it is reasonable to assume that a common environmental component (HGH or other shared exposure) contributed to the development of both melanomas. Because of the increased use of exogenous HGH as an antiaging agent, it is important to be aware of the growth-promoting effects of this hormone. Until better data are available that determines the true risk of exogenous HGH, its use as an antiaging agent merits increased surveillance. Arch Dermatol. 2012;148(10):1179-1182