Endogenous retroviruses and multiple sclerosis. II. HERV-7q
Endogenous retroviruses and multiple sclerosis. II. HERV-7q
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DOI：
10.1016/s0764-4469(99)80026-2
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发表时间：
1998-10-01
期刊：
影响因子：
--
通讯作者：
Rieger, F
中科院分区：
文献类型：
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作者：
Alliel, PM;Perin, JP;Rieger, F
在最近报道的多发性硬化症相关逆转录病毒（MSRV）的pol基因序列同源性的基础上，寻找新的内源性逆转录病毒序列，使我们能够确定位于人类7号染色体长臂上的全长内源性逆转录病毒序列。逆转录病毒HERV-7q在其env区，在一个1 620 bp的开放阅读框内，包含一个664 bp的结构域，几乎与rab7基因的3'非编码区相同。包含HERV-7q的env和3' LTR区域的转录本已经被确定为表达序列标签，这表明这个env样基因可能编码一个538个氨基酸的蛋白质。(C)巴黎科学院/爱思唯尔。
The search for new endogenous retroviral sequences, on the basis of sequence homologies with the pol gene of the recently reported multiple sclerosis associated retrovirus (MSRV), allowed us to identify a full length endogenous retrovirus sequence located on the long arm of human chromosome 7. This retrovirus, HERV-7q, includes in its env region, within a single 1 620 bp open reading frame, a 664 bp domain almost identical to a 3' non-coding region of the rab7 gene. Transcripts encompassing both the env and the 3' LTR regions of HERV-7q have already been identified as expressed sequence tags, suggesting that this env-like gene might code for a 538 amino acid long deduced protein. (C) Academie des sciences / Elsevier, Paris.