Automated Quantitative Analysis of Retinal Microvasculature in Normal Eyes on Optical Coherence Tomography Angiography
Automated Quantitative Analysis of Retinal Microvasculature in Normal Eyes on Optical Coherence Tomography Angiography
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DOI：
10.1016/j.ajo.2016.06.008
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发表时间：
2016-09-01
影响因子：
4.2
通讯作者：
Coscas, Gabriel
中科院分区：
文献类型：
--
作者：
Lupidi, Marco;Coscas, Florence;Coscas, Gabriel
目的：描述一种使用光学相干断层扫描血管造影（OCT-A）显示和分析黄斑血管灌注的新自动化定量技术，并确定规范数据集，该数据集可用作识别不同视网膜血管疾病引起的进行性变化的参考。设计：可靠性研究。方法：对用光谱成像成像的 47 名连续健康受试者的 47 只眼睛进行回顾性评价。域 OCT-A 设备在单一机构进行。全谱振幅去相关血管造影生成视网膜浅层和深层毛细血管丛的 OCT 血管造影。使用全自动定制软件提供有关中央凹无血管区（FAZ）特征以及总血管和无血管表面的定量数据。对中心黄斑厚度（和体积）和 FAZ 指标进行了比较分析。还评估了重复性和再现性，以确定该方法的可行性和可靠性。结果：浅层毛细血管丛和深层毛细血管丛之间的比较分析显示，在考虑总血管和无血管表面时，存在统计学显着差异（P<0.05）。黄斑中心厚度（和体积）与 FAZ 表面之间存在线性相关性。重复性和再现性系数小于 0.4，从而证明所有检查数据具有较高的观察者内重复性和观察者间再现性。结论：Spectralis OCT 血管造影上可见的视网膜血管灌注定量方法可能为监测几种视网膜血管疾病的疾病进展提供客观可靠的方法。 (C) 2016 Elsevier Inc. 保留所有权利。
PURPOSE: To describe a new automated quantitative technique for displaying and analyzing macular vascular perfusion using optical coherence tomography angiography (OCT-A) and to determine a normative data set, which might be used as reference in identifying progressive changes due to different retinal vascular diseases.DESIGN: Reliability study.METHODS: A retrospective review of 47 eyes of 47 consecutive healthy subjects imaged with a spectral-. domain OCT-A device was performed in a single institution. Full-spectrum amplitude-decorrelation angiography generated OCT angiograms of the retinal superficial and deep capillary plexuses. A fully automated custom-built software was used to provide quantitative data on the foveal avascular zone (FAZ) features and the total vascular and avascular surfaces. A comparative analysis between central macular thickness (and volume) and FAZ metrics was performed. Repeatability and reproducibility were also assessed in order to establish the feasibility and reliability of the method.RESULTS: The comparative analysis between the superficial capillary plexus and the deep capillary plexus revealed a statistically significant difference (P .05) when considering total vascular and avascular surfaces. A linear correlation was demonstrated between central macular thickness (and volume) and the FAZ surface. Coefficients of repeatability and reproducibility were less than 0.4, thus demonstrating high intraobserver repeatability and interobserver reproducibility for all the examined data.CONCLUSIONS: A quantitative approach on retinal vascular perfusion, which is visible on Spectralis OCT angiography, may offer an objective and reliable method for monitoring disease progression in several retinal vascular diseases. (C) 2016 Elsevier Inc. All rights reserved.