A NEW ONE-TRIAL TEST FOR NEUROBIOLOGICAL STUDIES OF MEMORY IN RATS .3. SPATIAL VS NONSPATIAL WORKING MEMORY
A NEW ONE-TRIAL TEST FOR NEUROBIOLOGICAL STUDIES OF MEMORY IN RATS .3. SPATIAL VS NONSPATIAL WORKING MEMORY
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DOI：
10.1016/s0166-4328(05)80315-8
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发表时间：
1992-10-31
影响因子：
2.7
通讯作者：
MELIANI, K
中科院分区：
文献类型：
--
作者：
ENNACEUR, A;MELIANI, K
大鼠接受了物体和空间识别测试(两者都基于相同的范式)，并接受了放射臂迷宫。结果表明：(1)大鼠在保持延迟为1min、15min、60min而不是24h时，能够分辨新物体和熟悉物体，辨别水平与实验间延迟呈二次曲线关系，最大辨别时间为15min。(2)在保持延迟期间暴露于分心刺激可能会损害物体识别。(3)大鼠对新的空间和熟悉的空间进行了区分。(4)关于工作记忆的多种形式，尤其是空间和非空间形式的工作记忆，三种测验之间没有相关性。(5)内侧隔损毁对物体和空间再认记忆无明显损害，但空间再认测验的辨别水平显著低于对照组。
Rats were submitted to object and spatial recognition tests (both based on the same paradigm) and to the radial-arm maze. The results are as follows: (1) rats could discriminate between a new and a familiar object when the retention delay was 1 min, 15 min or 60 min but not 24 h. The relationship between the level of discrimination and intertrial delays is quadratic with a maximum for 15 min. (2) Exposure to distractive stimuli during the retention delay may impair object recognition. (3) Rats discriminated between a new and a familiar space. (4) There is no correlation between the three tests which argues for a multiple form of working memory, especially a spatial and a non-spatial one. (5) Medial septal lesion did not impair object and spatial recognition memory, but the level of discrimination in the spatial recognition test was significantly reduced compared to that of control.