PREVALENCE OF AND MORTALITY FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE-2 IN BISSAU, WEST-AFRICA
PREVALENCE OF AND MORTALITY FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE-2 IN BISSAU, WEST-AFRICA
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DOI：
10.1016/s0140-6736(89)92281-2
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发表时间：
1989-04-15
期刊：
影响因子：
168.9
通讯作者：
DIAS, F
中科院分区：
文献类型：
--
作者：
POULSEN, AG;AABY, P;DIAS, F
1987 年，西非比绍进行了一项以社区为基础的艾滋病毒感染流行率研究，要求随机选择 100 个“房子”中的人口参加。 89% (1329/1499) 接受了检查并采集了血样。没有人 HIV-1 血清呈阳性，但 4.7% 的 HIV-2 血清呈阳性（儿童为 0.6%，15 岁及以上人群为 8.9%，40 岁及以上人群为 20%）。当考虑到年龄时，地区、民族之间或不同公民身份的个人之间的血清流行率没有显着差异。性接触和输血是主要传播途径，未发现垂直传播病例。 HIV-2 血清阳性指标者配偶的 HIV-2 血清阳性率为 40%。对于有输血史的儿童，HIV-2 血清阳性的相对风险为 103.6，成人为 2.4。排除配偶后，没有发现 HIV-2 血清阳性聚集。在平均观察时间为 325 天后的随访中，HIV-2 血清阳性者的死亡率过高。 HIV-2 血清阳性儿童的相对死亡风险为 60.8，成人为 5.0。
In a community based prevalence study of HIV infection in Bissau, West Africa, 1987, the population in 100 randomly selected "houses" was asked to participate. 89% (1329/1499) were examined and had a blood sample taken. None was HIV-1 seropositive but 4.7% were seropositive for HIV-2 (0.6% in children, 8.9% in those aged 15 years and over, 20% in those aged 40 years and over). There was no significant difference in seroprevalence between areas or ethnic groups or between individuals of different civil status when age was taken into account. Sexual contact and blood transfusions were the dominant transmission routes, and no case of vertical transmission was identified. The HIV-2 seroprevalence in spouses of HIV-2 seropositive index persons was 40%. For a history of blood transfusion the relative risk of being HIV-2 seropositive was 103.6 in children and 2.4 for adults. After exclusion of spouses, no clustering of HIV-2 seropositivity was seen. At follow-up, after a mean observation time of 325 days, there was an excess mortality for HIV-2 seropositives. The relative risk of dying for HIV-2 seropositive children was 60.8 and for adults 5.0.