Computational analysis on the mechanical interaction between a thrombus and red blood cells: Possible causes of membrane damage of red blood cells at microvessels
Computational analysis on the mechanical interaction between a thrombus and red blood cells: Possible causes of membrane damage of red blood cells at microvessels
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DOI：
10.1016/j.medengphy.2012.01.003
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发表时间：
2012-12-01
影响因子：
2.2
通讯作者：
Yamaguchi, Takami
中科院分区：
文献类型：
--
作者：
Kamada, Hiroki;Imai, Yohsuke;Yamaguchi, Takami
以往研究血栓形成的研究并没有集中在红细胞（RBC）和血栓之间的物理相互作用，尽管他们推测一些病理条件，如微血管病性溶血性贫血（MAHA）源于RBC和血栓之间的相互作用。在这项研究中，我们研究了止血过程中红细胞对原发性血栓的机械影响。探讨了血管内溶血的机制和加重因素。在存在和不存在红细胞的情况下的原发性血栓形成的计算机模拟表明，红细胞不太可能影响血栓的高度和覆盖范围，尽管它们的存在可能会改变微血管血流动力学和血小板运输到受伤的壁。我们的研究结果表明，由于红细胞膜损伤引起的血管内溶血可能受到三个血液动力学因素的促进：（1）血小板血栓的膨胀，因为更频繁的空间血栓形成减少了红细胞恢复其形状的时间，并迫使更严重的变形;（2）血小板血栓的硬度，因为更硬的血栓增加了碰撞时红细胞变形的程度;以及（3）血管尺寸和血细胞密度，因为较小的血管直径和较高的血细胞密度减小了RBC在更接近血栓时逃逸的空间，从而增强了血栓-RBC相互作用。(C)2012年IPEM。由爱思唯尔有限公司出版。保留所有权利。
Previous studies investigating thrombus formation have not focused on the physical interaction between red blood cells (RBCs) and thrombus, although they have been speculated that some pathological conditions such as microangiopathic hemolytic anemia (MAHA) stem from interactions between RBCs and thrombi. In this study, we investigated the mechanical influence of RBCs on primary thrombi during hemostasis. We also explored the mechanics and aggravating factors of intravascular hemolysis. Computer simulations of primary thrombogenesis in the presence and the absence of RBCs demonstrated that RBCs are unlikely to affect the thrombus height and coverage, although their presence may change microvessel hemodynamics and platelet transportation to the injured wall. Our results suggest that intravascular hemolysis owing to RBC membrane damage would be promoted by three hemodynamic factors: (1) dispersibility of platelet thrombi, because more frequent spatial thrombus formation decreases the time available for an RBC to recover its shape and enforces more severe deformation; (2) platelet thrombus stiffness, because a stiffer thrombus increases the degree of RBC deformation upon collision; and (3) vessel size and hemocyte density, because a smaller vessel diameter and higher hemocyte density decrease the room for RBCs to escape as they come closer to a thrombus, thereby enhancing thrombus-RBC interactions. (C) 2012 IPEM. Published by Elsevier Ltd. All rights reserved.