Brain white matter damage in SCA1 and SCA2. An in vivo study using voxel-based morphometry, histogram analysis of mean diffusivity and tract-based spatial statistics
Brain white matter damage in SCA1 and SCA2. An in vivo study using voxel-based morphometry, histogram analysis of mean diffusivity and tract-based spatial statistics
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DOI：
10.1016/j.neuroimage.2008.06.036
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发表时间：
2008-10-15
期刊：
影响因子：
5.7
通讯作者：
Mascalchi, Mario
中科院分区：
文献类型：
--
作者：
Della Nave, Riccardo;Ginestroni, Andrea;Mascalchi, Mario
背景和目的：脊髓小脑性共济失调1型（SCA 1）和2型（SCA 2）的神经变性与白色物质（WM）损害有关。基于体素的形态测量（VBM）、平均扩散率的直方图分析（MID）和基于道的空间统计（TBSS）使得能够对WM体积和结构进行体内定量分析。方法：对10例SCA1、10例SCA2和10例正常对照者进行MRI检查，包括T1加权像和弥散张量像。结果：VBM显示脑干和小脑WM萎缩，SCA1和SCA2之间无显著性差异。还存在大脑皮质下WM的局灶性萎缩。直方图分析显示，SCA1和SCA2患者的脑干和小脑MD增加，SCA2患者的MD更明显，SCA2患者的大脑半球MD轻度增加。在SCA1和SCA2中，TBSS显示下、中和上级小脑脚、脑桥横纤维、内侧和外侧丘系、脊髓丘脑束、皮质脊髓束和胼胝体的各向异性分数（FA）降低。SCA 2患者的神经束变化程度更大，并且短小脑内神经束的FA也减少。在这两种疾病的VBM，直方图和TBSS结果与临床severity.Conclusions：脑WM损害的特点是脑桥脑萎缩是相似的SCA1和SCA2，但更明显的SCA2。在这两种疾病中，它与临床缺陷的严重程度相关。(C)2008年爱思唯尔公司All rights reserved.
Background and purpose: Neurodegeneration in spinocerebellar ataxia type 1 (SCA1) and 2(SCA2) is associated with white matter(WM) damage. Voxel-Based Morphometry(VBM), histogram analysis of mean diffusivity (MID) and Tract-Based Spatial Statistics(TBSS) enable an in vivo quantitative analysis of WM volume and Structure. We assessed with these 3 techniques the whole brain WM damage in SCA1 and SCA2.Patients and methods: Ten patients with SCA1, 10 patients with SCA2 and 10 controls underwent MRI with acquisition of T1-weighted and diffusion tensor images. The results were correlated with severity of clinical deficit.Results: VBM showed atrophy of the brainstem and cerebellar WM without significant differences between SCA1 and SCA2. Focal atrophy of the cerebral subcortical WM was also present. Histogram analysis revealed increased MD in the brainstem and cerebellum in patients with SCA1 and SCA2 which in SCA2 was More pronounced and combined with mild increase of the MD in the cerebral hemispheres in SCA2. In SCA1 and SCA2 TBSS revealed decreased fractional anisotropy(FA) in the inferior, middle and superior cerebellar peduncles, pontine transverse fibres, medial and lateral lemnisci, spinothalamic tracts, corticospinal tracts and corpus callosum. The extent of tract changes Was greater in SCA2 patients who also showed decreased FA in the short intracerebellar tracts. In both diseases VBM, histogram and TBSS results correlated with clinical severity.Conclusions: Brain WM damage featuring a pontocerebeellar atrophy is similar in SCA1 and SCA2 but more pronounced in SCA2. In both diseases it correlates with severity of the clinical deficit. (C) 2008 Elsevier Inc. All rights reserved.