Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5.
Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5.
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DOI：
10.1126/science.284.5417.1155
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发表时间：
1999-05
期刊：
影响因子：
56.9
通讯作者：
Yangu Zhao;Hui Zhen Sheng;Reshad Amini;Alexander Grinberg;Eric Lee;S. Huang;Masanori Taira;Heiner Westphal
中科院分区：
文献类型：
--
作者：
Yangu Zhao;Hui Zhen Sheng;Reshad Amini;Alexander Grinberg;Eric Lee;S. Huang;Masanori Taira;Heiner Westphal
哺乳动物的海马体包含对认知功能如学习和记忆至关重要的神经回路。这种回路的发展取决于适当数量和类型的神经元的产生和正确放置。缺乏LIM同源框基因Lhx5功能的小鼠表现出海马发育的缺陷。海马神经前体细胞被指定和增殖，但他们中的许多人未能退出细胞周期或分化和迁移。因此，Lhx5是必不可少的前体细胞增殖的调节和海马发育过程中的神经元分化和迁移的控制。
The mammalian hippocampus contains the neural circuitry that is crucial for cognitive functions such as learning and memory. The development of such circuitry is dependent on the generation and correct placement of the appropriate number and types of neurons. Mice lacking function of the LIM homeobox gene Lhx5 showed a defect in hippocampus development. Hippocampal neural precursor cells were specified and proliferated, but many of them failed to either exit the cell cycle or to differentiate and migrate properly. Lhx5 is therefore essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development.