Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety
Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety
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DOI：
10.1016/j.psyneuen.2008.10.005
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发表时间：
2009-04-01
影响因子：
3.7
通讯作者：
O'Connor, Thomas G.
中科院分区：
文献类型：
--
作者：
Glover, Vivette;Bergman, Kristin;O'Connor, Thomas G.
母亲在怀孕期间的压力或焦虑会导致孩子的神经发育和其他问题，皮质醇是一种可能的中介。动物模型表明，母体产前应激可影响胎盘功能，包括调节胎盘11 β-HSD 2，这是皮质醇通过胎盘的主要障碍。目前尚不清楚人类是否存在类似的过程。本研究的目的是确定母亲的焦虑是否会增加母亲血浆皮质醇和羊水皮质醇之间的关联。样本包括262名妇女进行羊水穿刺术，正常妊娠，谁完成了斯皮尔伯格状态和特质焦虑量表，从他们的血浆样本和羊水的等分试样。母亲和羊水皮质醇之间的相关性强烈依赖于母亲的状态和特质焦虑;在最焦虑的状态四分位数r（62）= 0.59，p <0.001，在最不焦虑的状态四分位数r（60）= 0.05，ns，有显著差异（p <0.0015）。当控制孕龄、母亲年龄、胎儿性别、药物和采集时间时，母亲焦虑对母亲血浆和羊水皮质醇之间的关联的调节作用仍然存在。最焦虑组和最不焦虑组的母亲羊水皮质醇水平没有差异。然而，在更焦虑的孕妇中，母亲和胎儿的皮质醇之间存在更强的相关性，这一发现确实表明母亲的情绪状态会影响胎盘的功能。(C)2008爱思唯尔有限公司保留所有权利。
Maternal stress or anxiety during pregnancy can lead to neurodevelopmental and other problems in the child, and cortisol is one possible mediator. Animal models show that maternal prenatal stress can affect placental function, including regulation of placental 11 beta-HSD2, the main barrier to the placental passage of cortisol. It is not known whether a parallel process exists in humans. The aim of the current study was to determine whether maternal anxiety increases the association between maternal plasma cortisol and amniotic fluid cortisol. The sample consisted of 262 women having amniocentesis, with normal pregnancies, who completed Spielberger State and Trait anxiety scales, from whom a plasma sample and an aliquot of amniotic fluid was obtained. The correlation between maternal and amniotic fluid cortisol was strongly dependent on both State and Trait maternal anxiety; in the most anxious State quartile r(62) = .59, p < .001 and in the least r(60) = .05, ns, a significant difference (p < .0015). The moderating effect of maternal anxiety on the association between maternal plasma and amniotic fluid cortisol remained when gestational age, maternal age, fetal sex, medication and time of collection were controlled for. There was no difference in amniotic fluid cortisol levels between the most and least anxious groups of mothers. However, the finding that there is a stronger correlation between maternal and fetal cortisol among more anxious pregnant women does suggests that the maternal emotional state can affect the function of the placenta. (C) 2008 Elsevier Ltd. All rights reserved.