Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector.
Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector.
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DOI：
10.1364/boe.7.000279
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发表时间：
2016-02
影响因子：
3.4
通讯作者：
Yating Wang;Dong Xu;Sihua Yang;D. Xing
中科院分区：
文献类型：
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作者：
Yating Wang;Dong Xu;Sihua Yang;D. Xing
黑色素瘤是最危险的皮肤癌类型，致死率很高。肿瘤厚度和肿瘤相关血管是判断黑色素瘤分期的两个关键参数。以前诊断黑色素瘤的技术有难以克服的局限性，如侵入性、低特异性或不准确的深度测量。在这里，我们开发了一种集成的光声(PA)和超声(US)成像系统，致力于克服这些限制。PA/US组合成像策略采用声光同轴/共焦设计和灵活耦合方式的集成探测器。PA成像结果能够以高分辨率和高对比度清晰地表征肿瘤血管生成。此外，同时获得的PA/US图像可以解决不同阶段黑色素瘤的准确厚度测量问题。体模实验和活体动物实验结果表明，集成的PA/US系统可以为黑色素瘤的非侵入性活检提供潜在的可能性。
Melanoma is the most dangerous type of skin cancer with high lethal rate. Tumor thickness and tumor-associated vasculature are two key parameters for staging melanoma. Previous techniques for diagnosing melanoma have insurmountable restrictions, such as invasive, low specificity, or inaccurate depth measurement. Here we develop an integrated photoacoustic (PA) and ultrasound (US) imaging system dedicated to overcome these limitations. An integrated detector with sound-light coaxial/confocal design and flexible coupling mode is employed for the combined PA/US imaging strategy. PA imaging results enable a clear characterization of tumor angiogenesis with high resolution and high contrast. Furthermore, accurate thickness measurements of melanoma in different stages can be resolved with the simultaneously obtained PA/US image. Phantom experiments and in vivo animal experimental results demonstrate the integrated PA/US system could provide potential for noninvasive biopsy of melanoma.