Non-invasive imaging of the crystalline structure within a human tooth
Non-invasive imaging of the crystalline structure within a human tooth
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DOI：
10.1016/j.actbio.2013.06.018
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发表时间：
2013-09-01
影响因子：
9.7
通讯作者：
Cernik, Robert J.
中科院分区：
文献类型：
--
作者：
Egan, Christopher K.;Jacques, Simon D. M.;Cernik, Robert J.
利用X射线衍射计算机断层扫描技术，对人磨牙的内部晶体结构进行了非破坏性的横截面成像。对于坚硬的生物材料，来自具有大衰减长度的高能X射线的衍射信号被收集在传输几何中。结合计算机断层扫描数据采集和数学重建它们的空间原点，可以获得牙齿内每个体素的衍射图。利用这种方法，我们观察到了一些关键材料参数的空间变化，包括纳米晶尺寸、有机含量、晶格参数、晶体择优取向和取向度。我们还将单胞晶格参数的空间变化与牙齿的化学成分联系起来。此外，我们已经通过羟基磷灰石晶体的明显非晶化来确定龋齿是如何发生的，并且我们已经能够绘制出牙齿内的龋齿程度。该方法对矿化生物材料的无损探测具有很强的应用前景。(C)2013 Acta Materialia Inc.由Elsevier Ltd.出版。保留所有权利。
The internal crystalline structure of a human molar tooth has been non-destructively imaged in cross-section using X-ray diffraction computed tomography. Diffraction signals from high-energy X-rays which have large attenuation lengths for hard biomaterials have been collected in a transmission geometry. Coupling this with a computed tomography data acquisition and mathematically reconstructing their spatial origins, diffraction patterns from every voxel within the tooth can be obtained. Using this method we have observed the spatial variations of some key material parameters including nanocrystallite size, organic content, lattice parameters, crystallographic preferred orientation and degree of orientation. We have also made a link between the spatial variations of the unit cell lattice parameters and the chemical make-up of the tooth. In addition, we have determined how the onset of tooth decay occurs through clear amorphization of the hydroxyapatite crystal, and we have been able to map the extent of decay within the tooth. The described method has strong prospects for non-destructive probing of mineralized biomaterials. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.