Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer
Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer
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DOI：
10.1023/a:1010692132669
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发表时间：
2001-01-01
影响因子：
3.8
通讯作者：
Sugimachi, K
中科院分区：
文献类型：
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作者：
Kinoshita, J;Kitamura, K;Sugimachi, K
血管内皮生长因子- c （VEGF-C）是一种诱导淋巴管生成的特异性配体。我们检测了VEGF-C蛋白的表达，以确定其在乳腺癌进展中的作用。免疫组织化学分析显示，VEGF-C在98例乳腺癌标本中的39例（39.8%）中过表达，但在邻近的正常乳腺中没有过表达。VEGF-C表达与淋巴管侵袭有显著相关性（p = 0.0004）。值得注意的是，VEGF-C阳性组的5年无病生存率明显低于阴性组（p = 0.0356）。我们认为，由于VEGF-C的表达与淋巴扩散无关，它可能被证明是预测乳腺癌复发的一个有希望的标志物。
Vascular endothelial growth factor-C (VEGF-C) is a specific ligand which induces lymphangiogenesis. We examined the expression of VEGF-C protein to determine its role in the progression of breast cancer. Immunohistochemical analysis revealed that VEGF-C was overexpressed in 39 of 98 breast cancer specimens (39.8%) but not in adjacent normal mammary glands. The expression of VEGF-C showed a significant correlation with lymphatic vessel invasion (p = 0.0004). It is noteworthy that the 5-year disease free survival rate of the VEGF-C positive group was significantly poorer than that of negative group (p = 0.0356). We suggest that as expression of VEGF-C is not implicated in lymphatic spread, it may prove to be a promising marker to predict the recurrence of breast cancer.