Interaction analysis of gene variants of TCF7L2 and body mass index and waist circumference on type 2 diabetes
Interaction analysis of gene variants of TCF7L2 and body mass index and waist circumference on type 2 diabetes
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DOI：
10.1016/j.clnu.2019.01.014
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Lulu Zhang
中科院分区：
文献类型：
--
作者：
Linlin Li;Jinjin Wang;Zhiguang Ping;Yuqian Li;Chongjian Wang;Yuanyuan Shi;Wen Zhou;Lulu Zhang
Background & aims: Type 2 diabetes (T2D) is a complex metabolic disease with numerous risk factors,.including a growing number of genetic susceptibility variants. The TCF7L2 gene is closely associated with.an increased risk of type 2 diabetes, but the association of TCF7L2 with weight-related traits in humans is.unclear. The purpose of this study was to determine if TCF7L2 variants and body mass index/waist.circumference (BMI/WC) act synergistically to influence the incidence of type 2 diabetes in a Chinese.population..Methods: This is a large sample, caseecontrol study. We recruited 1842 Chinese type 2 diabetes patients.and 7777 healthy controls and collected demographic and anthropometric characteristics and blood.samples. We extracted DNA and genotyped the TCF7L2 single nucleotide polymorphisms rs7903146 and.rs290487 in all participants..Results: There were significant linear interactions between rs7903146 and BMI/WC and elevated blood.glucose (P < 0.001); rs290487 and BMI/WC also showed a linear interaction with blood glucose levels.(P < 0.001). The interactionwas stronger at higher BMI (>21.02) and higherWC (>66.77 cm). The additive.interaction of rs 290487 and overweight/obesity variables yielded a significant increase in the risk for.T2D. RERI (relative excess risk of interaction) was 2.949 (95%CI: 1.700e4.198), AP (attributable proportion.due to interaction) was 0.391 (95%CI: 2.281e0.502), and SI (synergy index) was 1.822 (95%CI: 1.463.e2.268). Additionally, there was a significant interaction between rs 290487 and abdominal obesity on.the risk of T2D (RERI: 2.642, 95%CI: 1.384e3.900; AP: 0.350, 95%CI: 0.231e0.468; SI: 1.675, 95%CI: 1.348.e2.083)..Conclusions: These results show that a TCF7L2 gene-BMI interaction or geneeWC interaction may play an.important role in the risk for T2D in the Chinese population.
