The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.
The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.
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DOI：
10.1177/0269881116658988
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Reinecke A
中科院分区：
文献类型：
--
作者：
Günthner J;Scholl J;Favaron E;Harmer CJ;Johansen-Berg H;Reinecke A
最近有越来越多的兴趣在药理学操作，可能会提高焦虑症的认知行为治疗为基础的焦虑症。一种这样的药物是部分NMDA激动剂d-环丝氨酸。有人认为d-环丝氨酸通过使学习更快来增强认知行为治疗。虽然动物研究支持这种药物加速学习的观点，但人类研究的证据却参差不齐。因此，我们设计了一个实验来测量d-环丝氨酸对人类运动学习的影响。54名健康志愿者被随机分配到单剂量的250毫克d-环丝氨酸与安慰剂在一个双盲设计。然后他们执行了运动序列学习任务。D-环丝氨酸没有增加运动学习的速度或学习的总量。然而，我们注意到，使用d-环丝氨酸的参与者往往反应更仔细（转向较慢但更正确的反应）。结果表明，d-环丝氨酸不发挥有益的影响，心理治疗通过机制参与运动学习。对其他认知机制的影响有待进一步研究。
There has recently been increasing interest in pharmacological manipulations that could potentially enhance exposure-based cognitive behaviour therapy for anxiety disorders. One such medication is the partial NMDA agonist d-cycloserine. It has been suggested that d-cycloserine enhances cognitive behaviour therapy by making learning faster. While animal studies have supported this view of the drug accelerating learning, evidence in human studies has been mixed. We therefore designed an experiment to measure the effects of d-cycloserine on human motor learning. Fifty-four healthy human volunteers were randomly assigned to a single dose of 250mg d-cycloserine versus placebo in a double-blind design. They then performed a motor sequence learning task. D-cycloserine did not increase the speed of motor learning or the overall amount learnt. However, we noted that participants on d-cycloserine tended to respond more carefully (shifting towards slower, but more correct responses). The results suggest that d-cycloserine does not exert beneficial effects on psychological treatments via mechanisms involved in motor learning. Further studies are needed to clarify the influence on other cognitive mechanisms.
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影响因子：
7.6
作者：
Scholl, Jacqueline;Guenthner, Jan;Kolling, Nils;Favaron, Elisa;Rushworth, Matthew F. S.;Harmer, Catherine J.;Reinecke, Andrea
通讯作者：
Reinecke, Andrea
影响因子：
2.6
作者：
Kuo, Min-Fang;Unger, Mandy;Nitsche, Michael A.
通讯作者：
Nitsche, Michael A.
影响因子：
2.5
作者：
Cherry, Kendra M.;Lenze, Eric J.;Lang, Catherine E.
通讯作者：
Lang, Catherine E.
影响因子：
6.7
作者：
Hofmann, Stefan G.;Otto, Michael W.;Smits, Jasper A.
通讯作者：
Smits, Jasper A.
DOI：
10.1073/pnas.1119527109
发表时间：
2012-07-03
影响因子：
11.1
作者：
Self, Matthew W.;Kooijmans, Roxana N.;Roelfsema, Pieter R.
通讯作者：
Roelfsema, Pieter R.