HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: A further expansion of the disease spectrum
HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: A further expansion of the disease spectrum
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DOI：
10.1002/ajh.20190
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发表时间：
2004-11-01
影响因子：
12.8
通讯作者：
Mehta, P
中科院分区：
文献类型：
--
作者：
Schichman, EA;McClure, R;Mehta, P
HIV感染患者发生B细胞肿瘤和浆细胞恶液质的风险增加。B细胞和浆细胞肿瘤都倾向于中等或高级别，并且经常与EB病毒相关。艾滋病毒感染患者也有较高的风险获得浆母细胞淋巴瘤。在此之前，仅注意到鼻窦、口腔胃肠道和肺部表现。在这份报告中，我们描述了一个41岁的男性艾滋病病毒感染谁开发多形，髓外浆母细胞淋巴瘤与EB病毒。我们回顾了他的恶性肿瘤的临床和免疫学特征，从而扩大了疾病谱，包括以前没有报道的其他部位（骨骼，睾丸）。2004年出版Wiley-Liss，Inc.（匕首）。
Patients with HIV infection are at increased risk for B-cell neoplasms and plasma cell dyscrasias. Both B cell and plasma cell tumors tend to be intermediate or high grade and are frequently associated with Epstein-Barr virus. Patients with HIV infection are also at higher risk of acquiring plasmablastic lymphoma. Until this time, only sinus, oral gastrointestinal, and lung manifestation have been noted. In this report we describe a 41-year-old male with HIV infection who developed multiple pleomorphic, extramedullary plasmablastic lymphomas associated with Epstein-Barr virus. We review the clinical and immunological features of his malignancy and thereby expand the spectrum of disease to include additional sites (bones, testicles) not previously reported. Published 2004 Wiley-Liss, Inc.(dagger).