Catabolic sites of human interferon-gamma.
Catabolic sites of human interferon-gamma.
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人干扰素-γ的分解代谢位点。
DOI：
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发表时间：
1985
影响因子：
3.8
通讯作者：
G. Lunghetti
中科院分区：
文献类型：
--
作者：
V. Bocci;A. Pacini;G. Pessina;L. Paulesu;M. Muscettola;G. Lunghetti
注射入兔体内的重组人干扰素-γ比天然干扰素-γ更快地从循环中消失。后者在注射后4h的血浆浓度与天然人干扰素-α相似，但其初始衰减曲线比天然人干扰素-α更快。这一结果表明，干扰素-γ具有不同于干扰素-α的药代动力学特性，这可能是由于肝脏和肾脏同时大量分解代谢所致。令人惊讶的是，肝脏对重组(非糖基化)干扰素-γ的摄取比对天然干扰素-伽马的摄取更显著。此外，两种干扰素-γ制剂均被离体肾和灌流肾清除，重组干扰素再次迅速消失。这一结果与干扰素-γ以四聚体形式存在的说法不一致，该四聚体不会被肾小球过滤，但与体内显示的药代动力学行为一致。
Recombinant human interferon-gamma (HuIFN-gamma) injected into rabbits disappeared from the circulation more rapidly than natural IFN-gamma. The latter displayed an initial decay curve more rapid than that for natural HuIFN-alpha although 4 h after injection plasma levels were similar. This result suggests that IFN-gamma has pharmacokinetic properties different to those of IFN-alpha which may be explained by considerable and simultaneous hepatic and renal catabolism. Surprisingly, the hepatic uptake of recombinant (unglycosylated) IFN-gamma was more marked than uptake of natural IFN-gamma. Moreover, both IFN-gamma preparations were cleared by the isolated and perfused kidney and once again the recombinant IFN disappeared more rapidly. This result does not conform with the suggestion that IFN-gamma exists as a tetramer which would not be filtered by the glomerulus, but is consistent with the pharmacokinetic behaviour shown in vivo.
人干扰素-γ被培养的成纤维细胞内化和降解。
DOI：
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发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Anderson,P;Yip,YK;Vilcek,J
通讯作者：
Vilcek,J