Catalytic and stereoselective ortho-lithiation of a ferrocene derivative.
Catalytic and stereoselective ortho-lithiation of a ferrocene derivative.
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DOI：
10.1002/anie.201303650
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发表时间：
2013-09
影响因子：
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通讯作者：
P. Steffen;C. Unkelbach;M. Christmann;W. Hiller;C. Strohmann
中科院分区：
文献类型：
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作者：
P. Steffen;C. Unkelbach;M. Christmann;W. Hiller;C. Strohmann
N，N-二甲基二茂铁甲胺（2）是Ugis胺的非手性类似物。因此，其通过邻位锂化的去对称化必须由手性助剂介导。这里存在一个主要的问题，限制了它作为前手性结构单元的应用：2的不对称锂化方法的转化率和/或立体选择性低，
N,N-Dimethylferrocenylmethylamine (2) is an inexpen-sive, achiral analogue of Ugis amine. Therefore, its desym-metrization by ortho-lithiation has to be mediated by chiralauxiliaries. Herein lies a principal problem that has limited itsuse as a prochiral building block to date: procedures for theasymmetric lithiation of 2 suffer from low conversion and/orstereoselectivities,