Regulation of Oocyte Growth in the Mouse Ovary
Regulation of Oocyte Growth in the Mouse Ovary
复制标题
小鼠卵巢中卵母细胞生长的调节
作者：
T. Krarup;T. Pedersen;M. Faber
小鼠出生时具有有限数量的卵母细胞，这些卵母细胞是在胎儿时期从原始卵原细胞及其直接有丝分裂后代1发育而来的。出生后不会形成新的卵母细胞，卵母细胞总数随着年龄的增长而减少。在生命的前两周，这种下降是由于小卵母细胞的退化，而后来几乎完全是由于发育中的卵母细胞的退化或排卵3。
MICE are born with a finite number of oocytes which develop in foetal life from primordial oogonia and their direct mitotic progeny1. After birth no new oocytes are formed, and the total number of oocytes decreases with advancing age2. During the first 2 weeks of life this decrease is due to degeneration of small oocytes while later it is almost solely due to degeneration of developing oocytes or to ovulation3.