Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer.
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer.
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人结直肠癌中MMPs表达及预后的综合分析
DOI：
10.3389/fonc.2021.771099
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发表时间：
2021
影响因子：
4.7
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Yu J;He Z;He X;Luo Z;Lian L;Wu B;Lan P;Chen H
背景研究表明基质金属蛋白酶（MMP）家族基因在肿瘤的侵袭、新生血管形成和转移中起重要作用。然而，24种MMPs在结直肠癌中的不同表达模式和预后价值尚待分析。方法本研究首先通过整合公共数据库和我们的资料，对结直肠癌患者MMPs的表达水平和蛋白水平进行研究。然后，通过使用TCGA和GEO数据集，我们评估MMPs与结直肠癌的临床病理参数和预后的关系。最后，利用cBioPortal在线工具分析了MMPs的变化，并对MMPs及其邻近基因进行了网络和通路分析。结果MMP 1、MMP 3、MMP 7、MMP 9-MMP 12和MMP 14在公开数据集和我们的样本中一致性上调。然而，MMP 28在公开数据集和我们的样本中一直下调。在临床病理分析中，MMP 11、MMP 14、MMP 16、MMP 17、MMP 19和MMP 23 B的上调与较高的肿瘤分期显著相关。在生存分析中，MMP 11、MMP 14、MMP 17和MMP 19的上调与较短的无进展生存期（PFS）时间和较短的无复发（RFS）时间显著相关。结论MMP 11、MMP 14、MMP 17和MMP 19是结直肠癌精确治疗的潜在靶点。
Background Previous study implicated that genes of matrix metalloproteinase (MMP) family play an important role in tumor invasion, neoangiogenesis, and metastasis. However, the diverse expression patterns and prognostic values of 24 MMPs in colorectal cancer are yet to be analyzed. Methods In this study, by integrating public database and our data, we first investigated the expression levels and protein levels of MMPs in patients with colorectal cancer. Then, by using TCGA and GEO datasets, we evaluated the association of MMPs with clinicopathological parameters and prognosis of colorectal cancer. Finally, by using the cBioPortal online tool, we analyzed the alterations of MMPs and did the network and pathway analyses for MMPs and their nearby genes. Results We found that, MMP1, MMP3, MMP7, MMP9–MMP12, and MMP14 were consistently upregulated in public dataset and our samples. Whereas, MMP28 was consistently downregulated in public dataset and our samples. In the clinicopathological analyses, upregulated MMP11, MMP14, MMP16, MMP17, MMP19, and MMP23B were significantly associated with a higher tumor stage. In the survival analyses, upregulated MMP11, MMP14, MMP17, and MMP19 were significantly associated with a shorter progression-free survival (PFS) time and a shorter relapse-free (RFS) time. Discussion This study implied that MMP11, MMP14, MMP17, and MMP19 are potential targets of precision therapy for patients with colorectal cancer.
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影响因子：
11.2
作者：
Papageorgis P;Cheng K;Ozturk S;Gong Y;Lambert AW;Abdolmaleky HM;Zhou JR;Thiagalingam S
通讯作者：
Thiagalingam S
影响因子：
11.2
作者：
Garg P;Sarma D;Jeppsson S;Patel NR;Gewirtz AT;Merlin D;Sitaraman SV
通讯作者：
Sitaraman SV
影响因子：
64.5
作者：
Liu J;Lichtenberg T;Hoadley KA;Poisson LM;Lazar AJ;Cherniack AD;Kovatich AJ;Benz CC;Levine DA;Lee AV;Omberg L;Wolf DM;Shriver CD;Thorsson V;Cancer Genome Atlas Research Network;Hu H
通讯作者：
Hu H
DOI：
10.1016/j.bbrc.2004.11.027
发表时间：
2005-01-14
影响因子：
3.1
作者：
Deng, H;Guo, RF;Lu, YY
通讯作者：
Lu, YY
影响因子：
4
作者：
Chen, Chen;Liu, Xiaoping;Li, Sheng
通讯作者：
Li, Sheng