Microstructure-based biomechanics of coronary arteries in health and disease.
Microstructure-based biomechanics of coronary arteries in health and disease.
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DOI：
10.1016/j.jbiomech.2016.03.023
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发表时间：
2016-08-16
影响因子：
2.4
通讯作者：
Kassab GS
中科院分区：
文献类型：
--
作者：
Chen H;Kassab GS
冠状动脉粥样硬化是发达国家死亡和残疾的主要原因。更深入地了解冠状动脉的机械特性及其对压力的机械反应对于临床预防和治疗具有重要意义。基于微观结构的血管模型可以在宏观和微观机械水平上预测每个组成结构的动脉机械反应。此类模型必须基于正常动脉的单个外膜和中层的结构参数（成分含量、定向角度和尺寸）和机械性能以及动脉粥样硬化动脉的结构和机械性能的变化的定量数据。健康冠状动脉的微观结构本构模型由胶原蛋白、弹性蛋白和平滑肌细胞三种主要力学成分组成，而动脉粥样硬化动脉模型应考虑其他成分，包括内膜、纤维斑块、脂质、钙化等。本文综述了正常和动脉粥样硬化动脉的形态、力学性能和微观结构本构模型的文献。 冠状动脉。它还概述了当前必须归档的知识差距，以推进这一重要研究领域，以了解血管疾病的发生、进展和临床治疗。当可以通过先进的成像技术获得患病血管的真实的患者特定的几何形状和材料特性时，突出显示患者特定的结构模型，以提供诊断、虚拟治疗计划和预后。
Coronary atherosclerosis is the major cause of mortality and disability in developed nations. A deeper understanding of mechanical properties of coronary arteries and hence their mechanical response to stress is significant for clinical prevention and treatment. Microstructure-based models of blood vessels can provide predictions of arterial mechanical response at the macro- and micro-mechanical level for each constituent structure. Such models must be based on quantitative data of structural parameters (constituent content, orientation angle and dimension) and mechanical properties of individual adventitia and media layers of normal arteries as well as change of structural and mechanical properties of atherosclerotic arteries. The microstructural constitutive models of healthy coronary arteries consist of three major mechanical components: collagen, elastin, and smooth muscle cells, while the models of atherosclerotic arteries should account for additional constituents including intima, fibrous plaque, lipid, calcification, etc. This review surveys the literature on morphology, mechanical properties, and microstructural constitutive models of normal and atherosclerotic coronary arteries. It also provides an overview of current gaps in knowledge that must be filed in order to advance this important area of research for understanding initiation, progression and clinical treatment of vascular disease. Patient-specific structural models are highlighted to provide diagnosis, virtual planning of therapy and prognosis when realistic patient-specific geometries and material properties of diseased vessels can be acquired by advanced imaging techniques.