Changing Ethnic Disparity in Ischemic Stroke Mortality in US Children After the STOP Trial
Changing Ethnic Disparity in Ischemic Stroke Mortality in US Children After the STOP Trial
复制标题
DOI：
10.1001/jamapediatrics.2013.89
复制
发表时间：
2013-08-01
期刊：
影响因子：
26.1
通讯作者：
Fullerton, Heather J.
中科院分区：
文献类型：
--
作者：
Lehman, Laura L.;Fullerton, Heather J.
重要性先前的一份报告显示，美国黑人儿童的中风死亡率高于白人儿童（1979-1998），这种差异部分可能是由于镰状细胞病，导致儿童缺血性中风的高风险。我们假设，自1998年镰状细胞性贫血卒中预防试验（STOP试验）发表以来，这种差异已经减少，该试验证明了长期输血对初级卒中预防的有效性。目的：评估美国儿童缺血性和出血性卒中（作为主要死亡原因）死亡率的人口统计学和长期趋势。
IMPORTANCE A prior report showed higher stroke mortality in US black children compared with white children (1979-1998), a disparity likely due in part to sickle cell disease, which leads to a high risk of childhood ischemic stroke. We hypothesized that this disparity has diminished since the publication of the Stroke Prevention Trial in Sickle Cell Anemia (STOP trial) in 1998 demonstrating the efficacy of long-term blood transfusions for primary stroke prevention.OBJECTIVE To evaluate the demographics and secular trends in mortality from ischemic and hemorrhagic stroke (as a primary cause of death) in US children (