Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
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DOI：
10.1016/s0140-6736(09)61258-7
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发表时间：
2009-10-01
期刊：
影响因子：
168.9
通讯作者：
Menendez, Clara
中科院分区：
文献类型：
--
作者：
Aponte, John J.;Schellenberg, David;Menendez, Clara
背景间歇性预防性治疗（IPT）是一种很有前途的婴儿疟疾控制策略。我们进行了一个汇总分析的安全性和有效性的婴儿（IPTi）与磺胺嘧啶乙胺嘧啶在Africa.Methods，我们汇集了6个双盲，随机，安慰剂对照试验（分别在坦桑尼亚，莫桑比克，加蓬和加纳进行），评估的疗效IPTi与磺胺嘧啶乙胺嘧啶。在所有试验中，在世卫组织扩大免疫规划提供的常规疫苗接种时，给予婴儿IPTi或安慰剂。临床疟疾发病率、贫血风险（红细胞压积）试验数据
Background Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.Methods We pooled data from six double-blind, randomised, placebo-controlled trials (undertaken one each in Tanzania, Mozambique, and Gabon, and three in Ghana) that assessed the efficacy of IPTi with sulfadoxine-pyrimethamine. In all trials, IPTi or placebo was given to infants at the time of routine vaccinations delivered by WHO's Expanded Program on Immunization. Data from the trials for incidence of clinical malaria, risk of anaemia (packed-cell volume