Exhaled breath condensate in pediatric asthma: Promising new advance or pouring cold water on a lot of hot air? A systematic review
Exhaled breath condensate in pediatric asthma: Promising new advance or pouring cold water on a lot of hot air? A systematic review
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DOI：
10.1002/ppul.22776
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发表时间：
2013-05-01
影响因子：
3.1
通讯作者：
Jaffe, A.
中科院分区：
文献类型：
--
作者：
Thomas, P. S.;Lowe, A. J.;Jaffe, A.
呼出气冷凝液（EBC）分析是一种简单的非侵入性技术，其允许重复收集呼吸样本，对受试者的不便最小。这些呼吸样本可以潜在地指示肺部疾病活动，并且由于易于收集，EBC正在成为呼吸系统疾病研究中有用的研究工具。它有可能被用于基于人群的研究，并在儿童哮喘的背景下，它可能被证明是有用的诊断和监测。方法采用系统评价的方法，对EBC标志物在儿童哮喘中的研究进行回顾性分析。结果大多数研究是横断面设计，结果表明，简单的化学实体，如氢离子（如pH值），过氧化氢和氮氧化物与儿童过敏性哮喘和急性发作有关。此外，更复杂的分子，包括白细胞三烯，白细胞介素和细胞因子，如白细胞介素IL-4和IL-5也在哮喘患者的呼吸中升高。结论EBC对哮喘患儿有一定的辅助诊断价值，可用于评价哮喘患儿的炎症状态。未来的研究可能能够进一步完善如何最好地收集EBC样本，解释它们，该技术有可能允许重复采样，这将允许进行自然史，发病机制和治疗反应的研究。小儿肺醇。2013; 48：419442. (c)2013 Wiley Periodicals，Inc.
Background Exhaled breath condensate (EBC) analysis is a simple non-invasive technique that allows repeated collection of breath samples with a minimum of inconvenience for the subject. These breath samples can potentially indicate lung disease activity and given the ease of collection, EBC is becoming a useful research tool in the study of respiratory diseases. It has the potential to be used in both population-based studies and in the context of pediatric asthma it may prove useful in diagnosis and monitoring. Methods A systematic review was conducted to identify studies of EBC markers in childhood asthma. Results Most of the studies were cross-sectional in design, and the results suggest that simple chemical entities such as hydrogen ions (as pH), hydrogen peroxide, and oxides of nitrogen are associated with pediatric allergic asthma and exacerbations. In addition, more complex molecules including leukotrienes, prostaglandins, and cytokines such as the interleukins IL-4 and IL-5 are also elevated in the breath of those with asthma. Conclusion EBC has the potential to aid diagnosis, and to evaluate the inflammatory status of asthmatic children. Future studies may be able to refine further how best to collect EBC samples, to interpret them, and the technique has the potential to allow repeated sampling which will allow studies of natural history, pathogenesis and response to treatment to be undertaken. Pediatr Pulmonol. 2013; 48:419442. (c) 2013 Wiley Periodicals, Inc.