Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch
Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch
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DOI：
10.1016/s0147-6513(03)00009-5
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发表时间：
2003-10-01
影响因子：
6.8
通讯作者：
Raisuddin, S
中科院分区：
文献类型：
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作者：
Sayeed, I;Parvez, S;Raisuddin, S
拟除虫菊酯类杀虫剂，包括溴氰菊酯，由于其环境持久性和毒性低，在害虫控制方案中被用作有机氯和有机磷的替代品。溴氰菊酯的生态毒理学后果，特别是其对鱼类和其他水生生物中抗氧化剂的影响，尚不清楚。我们研究了溴氰菊酯（0.75微克/升）的抗氧化剂在淡水鱼，点斑鳢Bloch，使用标准的实验室条件下的效果。单次暴露48 h，导致肾脏和肝脏中各种抗氧化酶和非酶抗氧化剂的诱导。这些抗氧化剂的诱导在鳃中不是很突出。事实上，某些抗氧化剂被发现在鳃中耗尽。各组织过氧化氢酶活性均降低。溴氰菊酯还诱导所有组织中的脂质过氧化，鳃显示最高水平。谷氨酰胺，这是一个建立在鱼类的非酶抗氧化剂，显着（P
The pyrethroid class of insecticides, including deltamethrin, are being used as substitutes for organochlorines and organophosphates in pest-control programs because of their low environmental persistence and toxicity. Ecotoxicological consequences of deltamethrin, particularly its effects on antioxidants in fish and other aquatic organisms, are not well understood. We investigated the effect of deltamethrin (0.75 mug/L) on antioxidants in a freshwater fish, Channa punctatus Bloch, using standard laboratory conditions. A single exposure for 48 h caused induction of various antioxidant enzymes and nonenzymatic antioxidants in kidney and liver. The induction of these antioxidants was not very prominent in gills. In fact, certain antioxidants were found to be depleted in gills. Catalase activity was decreased in all the tissues. Deltamethrin also induced lipid peroxidation in all the tissues, gills showing the highest levels. Glutathione, which is an established nonenzymatic antioxidant in fish, was significantly (P