Glutamine Metabolism in Cancer
Glutamine Metabolism in Cancer
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DOI：
10.1007/978-3-030-65768-0_2
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Le, Anne
中科院分区：
文献类型：
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作者：
Li, Ting;Copeland, Christopher;Le, Anne
新陈代谢是所有细胞功能的基本过程。几十年来，越来越多的证据表明新陈代谢与恶性细胞增殖之间存在关系。与正常分化细胞不同，癌细胞重新编程新陈代谢以满足其能量需求。这些细胞在许多代谢途径中表现出重要的修饰，例如糖酵解和谷氨酰胺分解，其中包括三羧酸 (TCA) 循环、电子传递链 (ETC) 和磷酸戊糖途径 (PPP)[1]。自从发现瓦尔堡效应以来，研究表明癌细胞的代谢在癌症的生存和生长中起着至关重要的作用。最近的研究表明，谷氨酰胺在癌症代谢中的参与比以前认为的更为重要。谷氨酰胺是一种具有胺和酰胺官能团的非必需氨基酸，是血液中循环最丰富的氨基酸[2]。本章讨论癌症中谷氨酰胺代谢的特征以及针对癌症治疗的谷氨酰胺代谢的治疗选择。
Metabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, cancer cells have reprogrammed metabolism in order to fulfill their energy requirements. These cells display crucial modifications in many metabolic pathways, such as glycolysis and glutaminolysis, which include the tricarboxylic acid (TCA) cycle, the electron transport chain (ETC), and the pentose phosphate pathway (PPP)[1]. Since the discovery of the Warburg effect, it has been shown that the metabolism of cancer cells plays a critical role in cancer survival and growth. More recent research suggests that the involvement of glutamine in cancer metabolism is more significant than previously thought. Glutamine, a nonessential amino acid with both amine and amide functional groups, is the most abundant amino acid circulating in the bloodstream [2]. This chapter discusses the characteristic features of glutamine metabolism in cancers and the therapeutic options to target glutamine metabolism for cancer treatment.