Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP)
Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP)
复制标题
DOI：
10.1016/j.neuroimage.2019.116223
复制
发表时间：
2020-01-01
期刊：
影响因子：
5.7
通讯作者：
Yuen, Kenneth
中科院分区：
文献类型：
--
作者：
Kampa, Miriam;Schick, Anita;Yuen, Kenneth
出于最近的可复制性危机，我们测试了功能性磁共振成像（fMRI）组激活在两个独立的样本的可复制性。一个相同的行为和功能磁共振成像测试电池的纵向调查压力恢复机制的美因茨弹性项目（MARP），并进行了发现（N = 54）和复制样本（N = 103）。该成套测验包括一个应激反应任务、一个奖赏敏感性任务、一个恐惧条件化和消退范式、两个意志重评价任务和一个情绪干扰抑制任务。组激活的可复制性用Jaccard指数和类内相关（ICC）进行了测试。总的来说，我们观察到在全脑水平上激活的可复制性良好到极好。只有少数对比显示出不令人满意的可复制性。单个感兴趣区域一级的可复制性一般较低。发现样本中激活程度较强的任务表现出较好的可重复性。
Motivated by the recent replicability crisis we tested replicability of functional magnetic resonance imaging (fMRI) group activations in two independent samples. An identical behavioral and fMRI test battery for the longitudinal investigation of stress resilience mechanisms was developed for the Mainz Resilience Project (MARP) and conducted in a discovery (N = 54) and a replication sample (N = 103). The test battery consisted of a stress reactivity task, a reward sensitivity task, a fear conditioning and extinction paradigm, two volitional reappraisal tasks and an emotional interference inhibition task. Replicability of group activations was tested with the Jaccard index and the Intra Class Correlation (ICC). Overall, we observed good to excellent replicability of activations at the whole brain level. Only a minority of contrasts showed unsatisfactory replicability. Replicability at the level of individual regions of interest (ROIs) was generally lower. Tasks with stronger activation in the discovery sample showed better replicability.