SCREENING TANZANIAN MEDICINAL-PLANTS FOR ANTIMALARIAL ACTIVITY
SCREENING TANZANIAN MEDICINAL-PLANTS FOR ANTIMALARIAL ACTIVITY
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DOI：
10.1016/0001-706x(94)90041-8
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发表时间：
1994-02-01
期刊：
影响因子：
2.7
通讯作者：
TANNER, M
中科院分区：
文献类型：
--
作者：
GESSLER, MC;NKUNYA, MHH;TANNER, M
选择了传统医学中常用来治疗疟疾的 43 种不同植物，并筛选了它们对恶性疟原虫的体外抗疟活性。 43 种植物中的 13 种是直接从使用这些植物治疗疟疾的传统治疗师那里获得的。其他植物物种是根据文献中的民族医学信息收集的。植物材料采集自坦桑尼亚的莫罗戈罗、达累斯萨拉姆和卡盖拉地区。对这 43 种植物的 58 个植物样本进行了研究，包括叶子、根和茎皮。除了粗乙醇提取物外，还测试了这些提取物的石油醚 (PE)、乙酸乙酯 (EtAc) 和 H2O 馏分。体外测试表明，37%的研究植物表现出很强的抗疟活性，IC50值低于10μg/ml。四种最活跃的植物包括 Cissampelos mucronata、Maytenus senegalensis、Salacia madagascariensis 和 Zanthoxylum chalybeum。
Forty-three different plant species commonly used in traditional medicine for the treatment of malaria were selected and screened for their antimalarial activity against Plasmodium falciparum in vitro. Thirteen of the 43 species were obtained directly from traditional healers who use these plants for the treatment of malaria. The other plant species were collected on the basis of ethnomedicinal information in the literature. The plant material was collected from Morogoro, Dar es Salaam and Kagera regions in Tanzania. Fifty-eight plant samples from these 43 plant species, including leaves, roots and stem bark, were investigated. Apart from the crude EtOH extracts, petroleum ether (PE), ethyl acetate (EtAc) and H2O fractions of these extracts were also tested. The in vitro testing revealed that 37% of the investigated plants showed strong antimalarial activity with IC50 values below 10 mu g/ml. The four most active plants included Cissampelos mucronata, Maytenus senegalensis, Salacia madagascariensis and Zanthoxylum chalybeum.