Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome
Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome
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DOI：
10.1212/wnl.57.7.1307
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发表时间：
2001-10-09
期刊：
影响因子：
9.9
通讯作者：
Tatsch, K
中科院分区：
文献类型：
--
作者：
Eisensehr, I;Wetter, TC;Tatsch, K
用多导睡眠图、[I-123]-(N)-(3-碘丙基-2-基)-2-β-甲氧基-3-(4-氯苯基)托烷(I-123-IPT)SPECT和[I-123]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl]苯甲酰胺(I-123-IBZM)SPECT对14例未用药和11例左旋多巴治疗的特发性不宁腿综合征患者和10例正常对照进行了检查。未用药和左旋多巴治疗的RLS患者和对照组显示相似的纹状体多巴胺转运体和多巴胺D-2受体结合，后者随着年龄的增长而下降。作者得出结论，在药物初治和左旋多巴治疗的RLS患者中，纹状体多巴胺转运体和受体密度是正常的。
Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [I-123]-(N)-(3-iodopropen-2-yl)-2 beta -carbomethoxy-3 beta-(4-chlorophenyl) tropane (I-123-IPT) SPECT, and [I-123]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide (I-123-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D-2-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.