Acceleration of growth in two children treated with human growth hormone-releasing factor.
Acceleration of growth in two children treated with human growth hormone-releasing factor.
复制标题
使用人类生长激素释放因子治疗的两名儿童的生长加速。
DOI：
10.1056/nejm198501033120102
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Blizzard,RM
中科院分区：
文献类型：
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作者：
Thorner,MO;Reschke,J;Chitwood,J;Rogol,AD;Furlanetto,R;Rivier,J;Vale,W;Blizzard,RM
两名生长激素缺乏儿童接受生长激素释放因子治疗6个月。选择每公斤体重1 ~ 3 μg的给药模式，每3小时1分钟通过输液泵皮下给药，以模拟正常儿童的生长激素分泌。在治疗的第一周，两名儿童都有生长激素分泌增加的代谢影响，即氮潴留，表现为氮排泄减少（P<0.05），尿钙排泄增加（P<0.01）。在整个6个月的时间内，生长激素释放因子脉冲后，生长激素分泌增加，生长加速。一名儿童以每年7.1厘米的速度生长，而治疗前为每年4.6厘米；另一组生长速度为13.7 cm /年，而治疗前为2.1 cm /年，血清生长激素C水平升高。生长激素释放因子可恢复生长激素分泌及其生物学效应，包括氮潴留增加，血清生长激素C升高，生长激素缺乏症儿童线性生长加速。现在推测这种药物在治疗生长激素缺乏症儿童中的作用还为时过早。（中华医学杂志1985；31:4 - 9）
Two growth hormone–deficient children were treated with growth hormone–releasing factor for six months. The pattern of administration — 1 to 3 μg per kilogram of body weight, given subcutaneously over one minute every three hours by infusion pump — was chosen to simulate growth hormone secretion in normal children. During the first week of therapy, both children had evidence of the metabolic effects of increased growth hormone secretion — i.e., nitrogen retention, demonstrated by decreased nitrogen excretion (P<0.05), and increased urinary calcium excretion (P<0.01).Growth hormone secretion was increased after pulses of growth hormone–releasing factor during the entire six-month period, and growth was accelerated. One child grew at a rate of 7.1 cm per year, as compared with 4.6 cm per year before therapy; the other grew at a rate of 13.7 cm per year, as compared with 2.1 cm per year before therapy, and had increased serum levels of somatomedin C.Growth hormone–releasing factor can restore growth hormone secretion and its biologic effects, including an increase in nitrogen retention, an increase in serum somatomedin C, and acceleration of linear growth in children with growth hormone deficiency. It is premature to speculate how useful this agent will prove to be in the treatment of children with growth hormone deficiency. (N Engl J Med 1985;312:4–9.)