Quantitative renal function assessment of atheroembolic renal disease using view-shared compressed sensing based dynamic-contrast enhanced MR imaging: An in vivo study
Quantitative renal function assessment of atheroembolic renal disease using view-shared compressed sensing based dynamic-contrast enhanced MR imaging: An in vivo study
复制标题
使用基于视图共享压缩感知的动态对比增强 MR 成像对动脉粥样硬化性肾病进行定量肾功能评估：一项体内研究
DOI：
10.1016/j.mri.2019.10.007
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发表时间：
2020-01-01
影响因子：
2.5
通讯作者：
Zhang, Jue
中科院分区：
文献类型：
--
作者：
Kong, Hanjing;Chen, Bin;Zhang, Jue
动脉粥样硬化性肾病（AERD）是老年人肾功能不全的主要原因，尤其是由于其非特异性表现和栓塞事件的突然发生，AERD的诊断经常被延迟甚至漏诊。 探讨基于视图共享压缩感知（VCS）的动态对比增强磁共振成像（DCE-MRI）在动物模型中评估AERD的可行性。首先使用三只健康兔子评估基于 VCS DCE-MRI 的肾小球滤过率 (GFR) 估计的再现性。然后建立单侧AERD动物模型。所有兔子均接受了 VCS DCE-MRI，并通过常用的皮质室模型估计了 GFR 图。然后将栓塞肾脏的全肾和可疑病变区域的GFR值与正常肾脏的相应值进行比较。最后，通过相应的肾脏标本和组织学检查结果确认可疑病变区域。使用变异系数和 Bland-Altman 分析来分析 GFR 测量的再现性。使用学生 t 检验比较正常肾脏和栓塞肾脏的 GFR 值。在 2.5 秒的时间分辨率下获得具有足够诊断质量和减少运动伪影的对比度增强图像。 Bland-Altman 图表明，根据健康兔子的日间扫描估算的 GFR 值之间非常一致。此外，在基于区域的比较中，正常肾脏和AERD肾脏的像素级GFR值之间存在显着差异（P < 0.0001）。可疑病变与肾脏标本和组织学结果一致。初步动物研究验证了VCS DCE-MRI评估肾功能的可行性，该策略可能为识别AERD提供有价值的工具。
Atheroembolic renal disease (AERD) is the major cause of renal insufficiency in the elderly, and particularly, the diagnose of AERD is often delayed and even missed due to its nonspecific presentation and the sudden occurrence of an embolic event.To investigate the feasibility of the view-shared compressed sensing (VCS) based dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in the assessment of AERD in animal models. The reproducibility of VCS DCE-MRI based glomerular filtration rate (GFR) estimation was first evaluated using the three healthy rabbits. Animal models of unilateral AERD were then conducted. All the rabbits underwent VCS DCE-MRI and the GFR maps were estimated by a commonly used cortical-compartment model. The whole kidney and suspicious lesion region GFR values of embolized kidneys were then compared with the corresponding values of normal kidneys. Finally, the suspicious lesion regions were confirmed by the corresponding renal specimens and histological findings. The reproducibility of GFR measurements was analyzed using the coefficient of variation and Bland-Altman analysis. The GFR values of normal and embolized kidneys were compared using the Student t-test.Contrast-enhanced images with sufficient diagnostic quality and reduced motion artifacts are obtained at a temporal resolution of 2.5 s. The Bland-Altman plot indicated close agreement between the GFR values estimated from between-day scans in healthy rabbits. Besides, there existed significant differences between the pixel-wise GFR values of normal and AERD kidneys in region-based comparison (P < 0.0001). The suspicious lesions are consistent well with the renal specimen and histological findings.The preliminary animal study verified the feasibility of VCS DCE-MRI for renal function evaluation, and the strategy could potentially provide a valuable tool to identify AERD.