Vascular endothelial growth factor expression in the endometrium during the menstrual cycle, implantation window and early pregnancy
Vascular endothelial growth factor expression in the endometrium during the menstrual cycle, implantation window and early pregnancy
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DOI：
10.1097/01.gco.0000175362.12470.e0
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发表时间：
2005-08
影响因子：
2.1
通讯作者：
L. Nardo
中科院分区：
文献类型：
--
作者：
L. Nardo
综述目的：综述血管内皮生长因子在月经周期、着床窗和早孕期正常子宫内膜中的表达及其意义。血管生成对于子宫内膜的发育以及胚胎植入和妊娠的建立至关重要。许多细胞因子和生长因子，包括血管内皮生长因子，已知在体外和体内调节人子宫内膜中的血管生成。子宫内血管内皮生长因子的表达已被证明是受调控的周期依赖性的方式。近年来的研究表明，女性性类固醇激素和促性腺激素参与子宫内膜腺上皮细胞和间质细胞对血管内皮生长因子的调节。血管内皮生长因子水平在围着床期、分泌后期和月经前期增加。此外，这种血管生成生长因子的产生似乎与蜕膜化有关。血管内皮生长因子是人子宫内膜血管生成和血管功能的关键调节因子。异常的子宫内膜血管生成可能导致月经功能障碍、着床失败和早期妊娠流产。增强或抑制子宫内膜血管生成活性的可能性将为生殖功能的操纵提供一种新的方法。
Purpose of review The review aims to summarize recent data about vascular endothelial growth factor and its implications in the normal endometrium during the menstrual cycle, implantation window and early pregnancy. Recent findings Angiogenesis is crucial for the development of endometrium as well as for embryo implantation and establishment of pregnancy. A number of cytokines and growth factors including vascular endothelial growth factor are known to modulate angiogenesis in human endometrium in vitro and in vivo. Intrauterine vascular endothelial growth factor expression has been shown to be regulated in a cycle-dependent fashion. Recent studies have demonstrated that female sex steroid hormones and gonadotrophins contribute to the regulation of vascular endothelial growth factor by endometrial glandular epithelial and stromal cells. Vascular endothelial growth factor levels increase around the peri-implantation period and in the late secretory and pre-menstrual phases. Further, the production of this angiogenic growth factor appears to be related to decidualization. Summary Vascular endothelial growth factor is a key regulator of angiogenesis and vascular function in the human endometrium. Aberrant endometrial angiogenesis may result in menstrual dysfunction, failed implantation and first-trimester miscarriage. The possibility of enhancing or inhibiting angiogenic activity in the endometrium will provide a novel approach to the manipulation of reproductive functions.