Taurine feeding inhibits bile acid absorption from the ileum in rats fed a high cholesterol and high fat diet.
Taurine feeding inhibits bile acid absorption from the ileum in rats fed a high cholesterol and high fat diet.
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DOI：
10.1007/978-0-387-75681-3_29
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发表时间：
2009
影响因子：
--
通讯作者：
N. Nishimura;Tatsuro Yamamoto;T. Ota
中科院分区：
文献类型：
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作者：
N. Nishimura;Tatsuro Yamamoto;T. Ota
我们以前报道过，在胆固醇喂养的大鼠中，牛磺酸介导的血浆胆固醇降低是由胆汁酸排泄到粪便中的增加引起的。在本研究中，我们研究了牛磺酸对胆汁酸分泌到胆汁和胆汁酸从回肠吸收的影响。将雄性Wistar大鼠分为2组，一组饲喂含1%胆固醇的HC饲粮，另一组饲喂添加1%牛磺酸的HC饲粮，持续2周。测定肠系膜血、回肠远端及结肠食糜胆汁酸浓度。饲喂牛磺酸饲料的大鼠回肠远端肠系膜胆汁酸浓度显著低于仅饲喂HC饲料的大鼠。饲喂牛磺酸的大鼠结肠胆汁酸浓度显著高于饲喂HC的大鼠，但回肠远端胆汁酸浓度不显著高于饲喂HC的大鼠。然而，两组的胆汁酸分泌到胆汁中是相似的。这些结果表明，从远端回肠到直肠胆汁酸的吸收受到牛磺酸的抑制。
We have previously reported that taurine-mediated reductions in plasma cholesterol in cholesterol-fed rats were caused by increased excretion of bile acids into feces. In the present study, we examined the effect of taurine on bile acid secretion into bile and the absorption of bile acids from the ileum. Male Wistar rats were divided into 2 groups, one group that was fed a diet containing 1% cholesterol (HC diet) and the other group fed a HC diet supplemented with 1% taurine for 2 weeks. Bile acid concentrations in the mesenteric blood, the distal ileum and the colorectal digesta were determined. Mesenteric bile acid concentration in the distal ileum was significantly lower in rats fed the taurine containing diet than in those fed only the HC diet. Colorectal, but not distal ileal, bile acid concentration was significantly higher in rats fed the taurine diet than in those fed the HC diet. However, the secretion of bile acids into the bile was similar in the two groups. These results suggest that the absorption of bile acids from the distal ileum to the rectum is inhibited by taurine.