Assessment of Susceptibility Risk Factors for ADHD in Imaging Genetic Studies
Assessment of Susceptibility Risk Factors for ADHD in Imaging Genetic Studies
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DOI：
10.1177/1087054716664408
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发表时间：
2019-05-01
影响因子：
3
通讯作者：
Gonzalez, J. R.
中科院分区：
文献类型：
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作者：
Vilor-Tejedor, N.;Alemany, S.;Gonzalez, J. R.
目的：ADHD由一系列症状组成，这些症状通常由于过度分散和过多的零而表现出异质性。统计推断通常是基于一种力量不足的二分结果。这项研究的主要目的是确定一个合适的概率分布来分析成像遗传学研究中的ADHD症状。方法：我们使用两个独立的儿童总体样本来评估基于计数数据的描述ADHD症状的标准概率分布的一致性。结果：我们发现零膨胀负二项分布(ZINB)对ADHD症状的建模效果最好。ZINB发现了一种与ADHD相关的遗传变异rs273342(微管相关蛋白[MAPRE2])(p值=2.73E-05)。该变异还与血管周围体积(Virchow-Robin间隙；p值和lt；1E-03)相关。当使用二分定义时，没有发现关联。结论：我们建议对ADHD症状进行适当的建模可以增加建立显著危险因素的统计能力。
Objective: ADHD consists of a count of symptoms that often presents heterogeneity due to overdispersion and excess of zeros. Statistical inference is usually based on a dichotomous outcome that is underpowered. The main goal of this study was to determine a suited probability distribution to analyze ADHD symptoms in Imaging Genetic studies. Method: We used two independent population samples of children to evaluate the consistency of the standard probability distributions based on count data for describing ADHD symptoms. Results: We showed that the zero-inflated negative binomial (ZINB) distribution provided the best power for modeling ADHD symptoms. ZINB reveals a genetic variant, rs273342 (Microtubule-Associated Protein [MAPRE2]), associated with ADHD (p value = 2.73E-05). This variant was also associated with perivascular volumes (Virchow-Robin spaces; p values < 1E-03). No associations were found when using dichotomous definition. Conclusion: We suggest that an appropriate modeling of ADHD symptoms increases statistical power to establish significant risk factors.