Relationships between [18F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia
Relationships between [18F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia
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DOI：
10.3988/jcn.2019.15.4.527
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发表时间：
2019-10-01
影响因子：
3.1
通讯作者：
Noh, Young
中科院分区：
文献类型：
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作者：
Jeong, Hye Jin;Yoon, Cindy W.;Noh, Young
背景与目的原发性进行性失语（PPA）分为三种亚型：非流利/语法缺失型（nfvPPA）、语义变异型（svPPA）和逻辑缺失型（lvPPA）。我们试图描述所有三种亚型的[F-18]-THK 5351保留模式，并确定与每个神经语言学评分相关的[F-18]-THK 5351保留的地形图。（3例nfvPPA，5例svPPA和5例lvPPA）和37例认知正常（NC）受试者，接受3.0特斯拉磁共振成像，[F-18]-THK 5351正电子发射断层扫描，和详细的神经心理测试PPA患者还参加了广泛的神经语言测试。结果nfvPPA患者在左额下回和中央前回的[F-18]-THK 5351保留率较高。在svPPA患者中，与NC组相比，[F-18]-THK 5351在前下和外侧颞叶皮质中的保留升高（左>右）。lvPPA患者的[F-18]-THK 5351主要滞留在顶叶下部、颞叶外侧和背外侧前额叶皮质以及楔前叶（左>右）。[F-18]-THK 5351保留在左下额叶区域与较低的流畅性评分相关。理解与[F-18]-THK 5351在左颞叶皮层的保留相关。重复与[F-18]-THK 5351保留在左下顶叶和后颞区，而命名困难与保留在左梭状和颞叶cortices.Conclusions的[F-18]-THK 5351保留的模式是很好地匹配的临床和放射学研究结果为每个PPA亚型，在协议的解剖和功能的位置，每个语言域。
Background and Purpose There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [F-18]-THK5351 retention across all three subtypes and determine the topography of [F-18]-THK5351 retention correlated with each neurolinguistic score.Methods We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [F-18]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. The PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [F-18]-THK5351 retention.Results The nfvPPA patients exhibited higher [F-18]-THK5351 retention in the the left inferior frontal and precentral gyri. In svPPA patients, [F-18]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (left>right). The lvPPA patients exhibited predominant [F-18]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (left>right). [F-18]-THK5351 retention in the left inferior frontal area was associated with lower fluency scores. Comprehension was correlated with [F-18]-THK5351 retention in the left temporal cortices. Repetition was associated with [F-18]-THK5351 retention in the left inferior parietal and posterior temporal areas, while naming difficulty was correlated with retention in the left fusiform and temporal cortices.Conclusions The pattern of [F-18]-THK5351 retention was well matched with clinical and radiological findings for each PPA subtype, in agreement with the anatomical and functional location of each language domain.