DNA sequences of Alu elements indicate a recent replacement of the human autosomal genetic complement.
DNA sequences of Alu elements indicate a recent replacement of the human autosomal genetic complement.
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Alu 元件的 DNA 序列表明人类常染色体遗传互补体最近发生了替换。
DOI：
10.1073/pnas.93.9.4360
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发表时间：
1996
影响因子：
11.1
通讯作者：
Deininger,PL
中科院分区：
文献类型：
--
作者：
Knight,A;Batzer,MA;Stoneking,M;Tiwari,HK;Scheer,WD;Herrera,RJ;Deininger,PL
中性核常染色体基因座的DNA序列，在不同的人群中进行比较，提供了一个以前未开发的角度到现代人类出现的模式和克里思，并与已发表的克隆遗传线粒体DNA和Y染色体测量人类多样性的关键比较。我们从三个常染色体位点获得了超过55个重复序列，其中包括不同人群的代表Alu重复序列，以及这些位点之一的其他类人猿物种的正向序列。核苷酸多样性非常低。大多数个体和种群是相同的。只有一个核苷酸的差异区分假定的祖先等位基因的后代。这些结果不同于那些预期的，如果等位基因从不同的古代人口保持通过多区域的连续性。所观察到的序列多态性的虚拟缺乏是现代人类最近单一起源的标志，具有古老种群的一般替换。
DNA sequences of neutral nuclear autosomal loci, compared across diverse human populations, provide a previously untapped perspective into the mode and tempo of the emergence of modern humans and a critical comparison with published clonally inherited mitochondrial DNA and Y chromosome measurements of human diversity. We obtained over 55 kilobases of sequence from three autosomal loci encompassing Alu repeats for representatives of diverse human populations as well as orthologous sequences for other hominoid species at one of these loci. Nucleotide diversity was exceedingly low. Most individuals and populations were identical. Only a single nucleotide difference distinguished presumed ancestral alleles from descendants. These results differ from those expected if alleles from divergent archaic populations were maintained through multiregional continuity. The observed virtual lack of sequence polymorphism is the signature of a recent single origin for modern humans, with general replacement of archaic populations.