Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022
Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022
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DOI：
10.1056/nejmoa2207323
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发表时间：
2022-07-21
影响因子：
158.5
通讯作者：
Orkin, Chloe M.
中科院分区：
文献类型：
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作者：
Thornhill, John P.;Barkati, Sapha;Orkin, Chloe M.
背景2022年4月之前，猴痘病毒在非洲流行地区以外很少报告人类感染。目前，世界各地都有病例发生。感染的传播、危险因素、临床表现和结局定义不清。MethodsWe形成了一个国际合作小组的临床医生谁有助于国际病例系列，以描述的介绍，临床过程和聚合酶链反应证实猴痘病毒感染的结果。我们报告了2022年4月27日至6月24日期间在16个国家的43个地点诊断出的528例感染。总体而言，98%的感染者为男同性恋或双性恋男性，75%为白色，41%为人类免疫缺陷病毒感染;中位年龄为38岁。在95%的感染者中，怀疑通过性活动传播。在该病例系列中，95%的人出现皮疹（64%的人出现皮疹）。
BackgroundBefore April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined. MethodsWe formed an international collaborative group of clinicians who contributed to an international case series to describe the presentation, clinical course, and outcomes of polymerase-chain-reaction-confirmed monkeypox virus infections. ResultsWe report 528 infections diagnosed between April 27 and June 24, 2022, at 43 sites in 16 countries. Overall, 98% of the persons with infection were gay or bisexual men, 75% were White, and 41% had human immunodeficiency virus infection; the median age was 38 years. Transmission was suspected to have occurred through sexual activity in 95% of the persons with infection. In this case series, 95% of the persons presented with a rash (with 64% having