Macular Pigment Optical Density and Measures of Macular Function: Test-Retest Variability, Cross-Sectional Correlations, and Findings from the Zeaxanthin Pilot Study of Response to Supplementation (ZEASTRESS-Pilot)
Macular Pigment Optical Density and Measures of Macular Function: Test-Retest Variability, Cross-Sectional Correlations, and Findings from the Zeaxanthin Pilot Study of Response to Supplementation (ZEASTRESS-Pilot)
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DOI：
10.3390/foods5020032
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发表时间：
2016-06-01
期刊：
影响因子：
5.2
通讯作者：
Jennings, Barbara J.
中科院分区：
文献类型：
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作者：
Iannaccone, Alessandro;Carboni, Giovannella;Jennings, Barbara J.
我们报告了ZEASTRESS-Pilot参与者(n=18)在黄斑功能测试中的短期测试-重新测试基线变异性，他们与黄斑色素光密度(MPOD)的横断面相关性，以及四个月(FUV4)20 mg/天玉米黄质(ZX)然后四个月洗涤(FUV8；n=24，年龄50-81岁)的效果。结果包括：偏心0.5度和2.0度的mPod(MPOD-0.5和-2.0)；对比敏感度(CS)；模式翻转视网膜电信号(PERG)波幅；暗适应650 nm中心凹视锥敏感度(DA650-FCS)；500 mN旁黄斑中心凹视杆敏感度(DA500-PFRS)。所有黄斑功能指标均表现出紧密的重测相关(皮尔逊相关系数范围为0.744~0.946)和低的变异系数(变异系数范围为1.13%~4.00%)。MPod与黄斑功能呈复杂相关。补充后，第1、4、8组的MPOD-0.5和MPOD-2.0均有增加(所有指标均p<0.0001)。持续的、延迟性的MPOD增加和少量但显著(p=0.012)的CS增加仅见于女性的FUV8。PERG在FUV4时显著增加(p=0.0006)，在FUV8时部分下降。总之，补充ZX后，MPOD显著增加。对DA-650FCS和DA-500FRS无影响。补充后CS和PERG波幅均增加，但其影响在男性和女性之间有所不同。更多的研究似乎有必要进一步证实和描述这些性别间的差异。
We report on the short-term test-retest baseline variability in macular function tests in ZEASTRESS-Pilot participants (n = 18), on their cross-sectional correlation with macular pigment optical density (MPOD), and on the effects of four months (FUV4) of 20 mg/day zeaxanthin (ZX), followed by a four-month washout (FUV8; n = 24, age 50-81 years old). Outcomes included: MPOD at 0.5 and 2.0 deg eccentricity (MPOD-0.5 and -2.0); contrast sensitivity (CS); pattern-reversal electroretinogram (PERG) amplitude; dark-adapted 650 nm foveal cone sensitivity (DA650-FCS); and 500 mn parafoveal rod sensitivity (DA500-PFRS). All measures of macular function showed close test-retest correlation (Pearson's r range: 0.744-0.946) and low coefficients of variation (CV range: 1.13%-4.00%). MPOD correlated in a complex fashion with macular function. Following supplementation, MPOD-0.5 and MPOD-2.0 increased at both FUV4 and FUV8 (p 0.0001 for all measures). Continued, delayed MPOD increase and a small, but significant (p = 0.012), CS increase was seen at FUV8 only in females. PERGs increased significantly at FUV4 (p = 0.0006), followed by a partial decline at FUV8. In conclusion, following ZX supplementation, MPOD increased significantly. There was no effect on DA-650 FCS or DA-500 PFRS. Both CS and PERG amplitudes increased following supplementation, but the effect varied between males and females. Additional studies appear warranted to confirm and characterize further these inter-gender differences.