T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine
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DOI：
10.4049/jimmunol.177.10.6780
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发表时间：
2006-11-15
影响因子：
4.4
通讯作者：
Mosmann, Tim R.
中科院分区：
文献类型：
--
作者：
Kobie, James J.;Shah, Pranav R.;Mosmann, Tim R.
CD 73（5 '-外核苷酸酶）由两种不同的小鼠CD 4 T细胞群表达：抑制T细胞增殖但不分泌IL-2的CD 25（+）（FoxP 3（+））T调节（Treg）细胞，和分泌IL-2但在标准Treg抑制剂测定中不抑制的CD 25（-）未定型引发前体Th（Thpp）细胞。Treg和Thpp细胞上的CD 73将细胞外5 '-AMP转化为腺苷。腺苷抑制Th 1和Th 2效应细胞的增殖和细胞因子分泌，即使靶细胞被抗CD 3和抗CD 28激活。这代表了Treg细胞的另外的抑制机制和Thpp细胞的先前未被认识到的抑制活性。炎症部位的Treg或Thpp细胞的浸润可能会将中性粒细胞或垂死细胞产生的5 '-AMP转化为抗炎介质腺苷，从而抑制过度的免疫反应。
CD73 (5'-ectonucleotidase) is expressed by two distinct mouse CD4 T cell populations: CD25(+) (FoxP3(+)) T regulatory (Treg) cells that suppress T cell proliferation but do not secrete IL-2, and CD25(-) uncommitted primed precursor Th (Thpp) cells that secrete IL-2 but do not suppress in standard Treg suppressor assays. CD73 on both Treg and Thpp cells converted extracellular 5'-AMP to adenosine. Adenosine suppressed proliferation and cytokine secretion of Th1 and Th2 effector cells, even when target cells were activated by anti-CD3 and anti-CD28. This represents, an additional suppressive mechanism of Treg cells and a previously unrecognized suppressive activity of Thpp cells. Infiltration of either Treg or Thpp cells at inflammatory sites could potentially convert 5'-AMP generated by neutrophils or dying cells into the anti-inflammatory mediator adenosine, thus dampening excessive immune reactions.